JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2010, Vol. 48 ›› Issue (2): 128-130.

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Expression of HLA-G in cervical cancer and its clinical significance

ZHENG  Ni1, WANG Chuanxin1, DENG Xiaomei2, ZHANG Jian1, KAN Shifen1,ZHANG Xin1, LI Wei1, DU Lutao1   

  1. 1. Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan 250012， China;
    2. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2009-09-30 Online:2010-02-16 Published:2010-02-16

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Abstract:

Objective  To detect expression of human leukocyte antigen protein G（HLA-G）in cervical cancer and explore its significance in the development of cervical cancer. Methods  The SP immunohistochemical method was used to detect the expression of HLA-G in 54 cervical cancer tissues and 16 normal cervix tissues and its relationship with clinical pathological characteristics of cervical cancer was analyzed. Results  The positive expression rate of HLA-G was 66.7％（36/54） in cervical cancer tissues, while no positive expression（0/16）was found in normal cervix tissues. The positive expression rate of HLA-G was closely related with clinical stage and differentiation degree（P＜0.05）, but was not related with age, histological classification, and lymph node metastasis（P＞0.05）. Conclusion  Expression of HLA-G in cervical tumors is significantly higher than that in normal cervix tissues, and HLA-G plays an important role in the development of cervical cancer.

Key words: Human leukocyte antigen protein G； Cervical carcinoma； Immunohistochemistry

CLC Number: 

  • R737.33
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