JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Association of single nucleotide polymorphism of the C1040T gene encoding TAFI with myocardial infarction

WANG Li-li1，XU Cheng-wei1，YU Chao1，ZHAO Jing-jie2，WU Xiao-ben1，JIANG Cui-ying1，DU Yi-meng3   

  1. 1. Department of Clinical Laboratory; 2. Laboratory of Clinical Molecular Biology； 3. Department of　Cardiology, Second Hospital of Shandong University
  • Received:2007-08-02 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24
  • Contact: XU Cheng-wei

PDF (PC)

484

Abstract: Objective To explore the association between encoding gene CPB2 polymorphism of thrombin activatable fibrinolysis inhibitor（TAFI）and myocardial infarction. MethodsPCRRFLP (Restriction fragment length polymorphism) method was used to determine the CPB2 gene polymorphism in patients with myocardial infarction（n=100） and healthy controls（n=90）. ResultsThe CPB2 genotyping（Thr/Thr，Thr/Ile and Ile/Ile） frequencies were 32（32%），53（53%）and 15（15%）in the MI group and 31（34.4%），49（54.4%），10（11.2%）in the control group, and the allelic frequencies（C and T）were 117（58.5%）and 83（41.5%） in the MI group and 111（61.7%）and 69（38.3%）in the control group. χ2 analysis showed nonsignificant differences in the Thr325Ile polymorphism distributions（χ2=0.6482，P=0.7232；χ2=0.3958，P=0.5292）；genotype and alleles distribution frequencies were in accordance with the HardyWeinberg equilibrium. ConclusionThe polymorphisms of TAFI gene are not related to myocardial infarction.

Key words: Thrombin activatable fibrinolysis inhibitor, Gene polymorphism, Myocardial infarction(TAFIa)

CLC Number: 

  • R541.4
[1] ZHANG Lin, WANG Yan, MA Xu, FAN Xuesong, YUAN Hui. Association between MTHFR polymorphism and serum homocysteine in patients with unstable angina pectoris [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 71-75.
[2] TIAN Zhongyan, LI Yuqian, LIU Xiaotian, SHI Yuanyuan, ZHANG Haiqing, ZHANG Xia, QIAN Xinling, YIN Lei, ZHAO Jingzhi, WANG Chongjian. Relationship between PSMD6 gene rs831571 locus polymorphism and the susceptibility of T2DM: a case-control study [J]. Journal of Shandong University (Health Sciences), 2018, 56(7): 51-56.
[3] ZHAO Qingqing, YIN Geping. Association between genetic polymorphisms of 5 genetic loci of TNF-α promoter and genetic susceptibility to cervical cancer [J]. Journal of Shandong University (Health Sciences), 2018, 56(2): 28-33.
[4] DU Jinge, CHEN Hui, YANG Xiaorong, LÜ Ming. Meta-analysis of the association between the STAT4 rs7574865 polymorphism and systemic lupus erythematosus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 95-102.
[5] WANG Yao, CHEN Yan-hong, CHEN Hong. Correlation between sensibility, and side effects of 5-FU and DPYD gene polymorphisms in periphrel blood of patients with colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 18-21.
[6] YANG Yong-rong, LI Jun, LIANG Ye, LI Jin-du, LAN Jia-fu, LI Tian-zi. The study on association of TNF-α-238G/A gene polymorphisms in patients with oral lichen planus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 10-11.
[7] LIU Weigang, LU Yun, LI Linlin, LI Yunqing, SHENG Xuewen, YIN Lei, ZHANG Gongyuan, ZHAO Jingzhi. Relationships between obese population-susceptibility and gene polymorphisms of neuropeptide Y and its receptor in a region of Henan Province, China [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(8): 98-101.
[8] HOU Lijun1, XING Lijian2, LI Guanghong1, LIU Yan3, QI Wenbo4. Association between vitamin D receptor gene ApaI polymorphism and impaired glucose tolerance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 51-54.
[9] XU Zhen-xing1, LIU Rui2， ZHAO Qian1, ZHANG Jun-sheng3, ZHU Shi-ming1. Relationship between matrix metalloproteinases-9 gene polymorphism and the cardiovascular remodeling in  hypertension patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(2): 61-64.
[10] QIU Shao-hui1, GUO Ming2. Analysis on RHD variants among RhD negative voluntary blood
donors in Linyi district of Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(8): 112-.
[11] LI Ling, CHEN Yong, YANG Chong-mei. Correlation study of single nucleotide polymorphism of multiple
drug resistance 1 and ulcerative colitis prednisone sensitivity [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(5): 99-102.
[12] GAO Chun-yan， LIU Yun-qiu. Correlation between leptin receptor gene Pro1019Pro polymorphisms and
obstructive sleep apnea hypopnea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 87-.
[13] WANG Ze-jun1, XU Cheng-wei1, MA Xiao-li2, ZHENG Yan2, JIA Yan-fei2, XIAO Dong-jie2, WANG Yun-shan2 . Effect of CPB2 gene silencing on TAFI expression and   metastasis in breast cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 57-.
[14] QIAO Wenjing1， GUO Nongjian1， DING Botong2， CHEN Yun1， ZHOU Yawei1. Combined measurement of HLA-DRB1*1501 and the TNF-α-308 gene polymorphism in predicting response to immunosuppressive
therapy for aplastic anemia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(7): 73-76.
[15] LI Dawei, JIAO Wei, WANG Tieliu, YAN Lei, REN Juchao, TIAN Sujian,XU Zhonghua, FAN Yidong, LIU Hainan. Heparan sulfate proteoglycan gene polymorphism and genetic susceptibility to calcium oxalate nephrolithiasis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(1): 89-93.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd