Journal of Shandong University (Health Sciences) ›› 2026, Vol. 64 ›› Issue (10): 54-59.doi: 10.6040/j.issn.1671-7554.0.2026.1066

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Pathogenesis and new intervention strategies of chronic kidney disease

WANG Xiaojie, ZHANG Yan, TANG Wei, XIE Yusheng, WANG Ziying, SUN Yu, LIU Min, YI Fan   

  1. School of Basic Medical Sciences, Shandong University, Jinan 250012, Shandong, China
  • Published:2026-10-10

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Abstract: Chronic kidney disease(CKD)poses a severe global public health burden, yet its pathogenesis remains incompletely understood and current therapies are limited, with poor prognosis. In particular, conventional anti-fibrotic strategies have shown limited success in clinical translation. Growing evidence suggests that disruption of the renal tissue microenvironment represents a central driver of kidney injury and disease progression. In this article, we highlight the emerging concept that restoration of microenvironmental homeostasis is fundamental to successful renal repair, delineate the cellular and molecular networks that coordinate injury responses, identify key therapeutic targets governing kidney regeneration and fibrosis, and discuss innovative strategies to promote adaptive repair while limiting chronic tissue remodeling. These advances redefine current concepts of CKD pathogenesis and provide a mechanistic foundation for the development of next-generation precision therapies aimed at restoring renal homeostasis and regenerative capacity.

Key words: Chronic kidney disease, Immunometabolism, Epigenetic regulation, Drug target discovery, Chimeric antigen receptor T cells

CLC Number: 

  • R692
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