Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 26-30.doi: 10.6040/j.issn.1671-7554.0.2022.0567

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Association between sleep disturbance and inflammatory cytokines in 203 patients with glioma

LI Huayu1, SHI Xiaohan1, ZHANG Xinrui1, LI Feng2   

  1. 1. School of Nursing and Rehabilitation, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Neurosurgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China
  • Published:2022-12-01

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Abstract: Objective To investigate the incidence of sleep disturbance and the inflammatory factors related to sleep disturbance in patients with glioma. Methods A total of 203 patients with glioma admitted during Dec. 2020 and Dec. 2021 were surveyed with Pittsburgh Sleep Quality Index(PSQI). The plasma inflammatory cytokines were measured. The independent risk factors of sleep disturbance were identified with univariate analysis and binary Logistic regression. The robustness and accuracy of the prediction model were confirmed with support vector machine(SVM)model. Results Of all 203 patients, 52.7% had sleep disturbance. Binary Logistic regression analysis showed that receiving surgery(OR=0.491, 95%CI=0.245-0.985, P=0.045)was a protective factor, while increased expressions of IL-1β(OR=1.838, 95%CI=1.070-3.158, P=0.028)and IL-6(OR=3.627, 95%CI=1.453-9.054, P=0.006)were risk factors. The results of SVM model demonstrated the area under the receiver operating characteristic(AUC)of the prediction model was 0.793, and the accuracy was 0.720(95%CI=0.575-0.838). Conclusion The incidence of sleep disturbance in glioma patients is high, and elevated expressions of IL-1β and IL-6 are closely related to the risk of sleep disturbance.

Key words: Glioma, Sleep disturbance, Inflammation, Cytokines, Biological mechanism

CLC Number: 

  • R739.41
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