Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (6): 51-56.doi: 10.6040/j.issn.1671-7554.0.2021.0296

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Correlation between vitamin D deficiency and depression in patients with type 2 diabetes mellitus

LIU Ping1,2, SONG Yuwen3, WANG Ping4, TIAN Guangwei1, ZHENG Fengjie3, LYU Li3, DU Jiaojiao3, ZHANG Jing2, ZHUANG Xianghua3, CHEN Shihong3   

  1. 1. The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Endocrinology, The First Peoples Hospital of Pingyuan, Pingyuan 253100, Shandong, China;
    3. Department of Endocrinology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China;
    4. Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China
  • Published:2021-06-10

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Abstract: Objective To investigate the correlation between vitamin D deficiency and depression in patients with type 2 diabetes mellitus(T2DM). Methods A total of 175 T2DM patients were selected and divided into the depression group(n=74)and non-depression group(n=101)according to the Self-Rating Depression Scale(SDS). Serum concentration of 25OHD was measured. Bone mineral density was measured with dual energy X-ray. The differences in 25OHD and BMD between the two groups were compared. The correlation between serum vitamin D level and SDS score was evaluated with Spearman correlation analysis. Multivariate Logistic regression analysis was performed for the variables with small P value in univariate analysis. The receiver operating characteristic curve(ROC)was drawn and the area under the curve(AUC)was calculated to evaluate the diagnostic value of vitamin D deficiency and bone mineral density in T2DM patients with depression. Results The serum level of 25OHD and bone mineral density of femoral neck, hip joint and lumbar 1-4 in the depression group were significantly lower than those in the non-depression group(P<0.05). The prevalence of vitamin D deficiency and osteoporosis in the depression group were higher than those in the non-depression group(P<0.05). Logistic regression analysis showed that vitamin D deficiency(OR: 8.748, 95%CI: 1.724-44.375, P=0.009)and osteoporosis(OR: 6.385, 95%CI: 2.358-17.291, P<0.001)were influencing factors of T2DM complicated with depression. Conclusion Vitamin D deficiency may be a risk factor of T2DM patients with depression. Active prevention and treatment of vitamin D deficiency may help improve the depressive state of T2DM patients.

Key words: Vitamin D, Depression, Osteoporosis, Type 2 diabetes mellitus

CLC Number: 

  • R587.2
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