Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (4): 100-104.doi: 10.6040/j.issn.1671-7554.0.2019.1418

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Correlation between anti-müllerian hormone and natural reproductive potential in women

GAO Renyuan1, ZHANG Jing2, LIU Fangfang2, LI Ruijing2, ZHANG Xiuqing3, QIN Yingying1   

  1. 1. Department of Reproductive Endocrinology, Center for Reproductive Medicine, Shandong University, Jinan 250021, Shandong, China;
    2. Department of Health Management, Center for Reproductive Medicine, Shandong University, Jinan 250021, Shandong, China;
    3. Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To evaluate the relationship between serum level of anti-müllerian hormone(AMH)and natural reproductive potential in women of childbearing age. Methods Clinical data of 601 women who underwent physical examination during Jan. 2016 and May 2018 were collected. The patients were divided into two groups: young age group(≤35 years old, n=292)and advanced age group(>35 years old, n=309). According to the level of AMH, the two group were further divided into three subgroups: low AMH(<1.0 ng/mL), normal AMH(1.0~3.5 ng/mL)and high AMH(>3.5 ng/mL)groups. All women were followed up for 12 months to observe the natural conception 山 东 大 学 学 报 (医 学 版)58卷4期 -高任远,等.抗苗勒管激素与女性自然妊娠能力的关联分析 \=-rate. Results During the follow-up of 12 months, 202(33.61%)participants were pregnant. The clinical pregnancy rate was 53.42%(156/292)in the young age group and 14.89%(46/309)in the advanced age group. In the young age group, the clinical pregnancy rate in high, normal and low AMH subgroups was 54.97%(94/171), 56.38%(53/94)and 33.33%(9/27), respectively, with no significant difference(P=0.09). In the advanced age group, the clinical pregnancy rate in high, normal and low AMH subgroups was 35.71%(15/42), 21.10%(23/109)and 5.06%(8/158), respectively. A strong correlation was observed between AMH and natural conception rate(P<0.05). The ROC curve showed that AMH had certain predictive value for natural reproductive potential in the advanced age group(AUCAMH=0.74). Conclusion Serum level of AMH is a promising predictor for fertility in advanced age women, but not in young women.

Key words: Anti-müllerian hormone, Age, Natural conception, Fertility

CLC Number: 

  • R711.75
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