Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (11): 81-84.doi: 10.6040/j.issn.1671-7554.0.2019.1435

Previous Articles     Next Articles

Analysis of the bronchodilator test of 122 patients with asthma

LI Yan, NIU Rui, WANG Chaochao   

  1. Department of Respiratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China
  • Published:2020-11-04

PDF (PC)

1524

Abstract: Objective To analyze the results and characteristics of pulmonary function test and bronchodilator test in patients with asthma, and to explore the value of pulmonary function test in diagnosis and curative effect of asthma. Methods Pulmonary function results of 122 patients with asthma in 2018 were collected. According to FEV1/FVC%, the cases were divided into normal group(n=30)and airflow restricted group(n=92). Airflow restricted group was further divided into mild group(n=63), moderately severe group(n=16)and severe group(n=13)based on FEV1. Then the data of different groups were analyzed. Results The positive rates of bronchodilator test were 16.7%, 58.7%, 81.3%, and 100.0% in normal group, mild group, moderately severe group, and severe group, respectively, with a statistical difference between different groups(χ2=35.8, P=0.001). There was no significant difference of improvement quantity and improvement rate between FEV1 and FVC in normal group(P=0.39, P=0.14). FEV1/FVC% values before and after bronchodilator test in moderately severe group and severe group were lower than that in mild group(before the test: χ2=52.16, P<0.001; after the test: χ2=49.49, P<0.001). FEV1/FVC% value was increased after bronchodilator test in all airflow restricted groups(all P<0.05). Only 9.8% of patients were released from air restriction after bronchodilator test, which were entirely from mild group. Conclusion Positive rate of bronchodilator test increases depending on the aggravation of airflow obstruction in patients with asthma. The patients with normal pulmonary function can also reveive the bronchodilator test. Specific flow volume loops are showed in positive cases of normal group. It is a lifelong process and needs individualized management in the control or treatment of asthma. Pulmonary function test examined regularly is beneficial to guide clinical treatment and manage asthma.

Key words: Pulmonary function test, Bronchodilator test, Asthma, Forced expiratory volume in one second, Forced expiratory volume in one second /forced vital capacity

CLC Number: 

  • R562.2+5
[1] Boulet LP, Reddel HK, Bateman E, et al. The Global Initiative for Asthma(GINA): 25 years later[J]. Eur Respir J, 2019, 54(2): 1900598. doi: 10.1183/13993003.00598-2019.
[2] 尹硕淼,陈远彬,郑燕婵,等.不同肺功能检查方式在支气管哮喘指南中的诊断价值比较[J].中国全科医学, 2018, 21(32): 3911-3914. YIN Shuomiao, CHEN Yuanbin, ZHENG Yanchan, et al. Comparison of diagnostic value in different pulmonary function tests in the guidelines of bronchial asthma[J]. Chinese General Practice, 2018, 21(32): 3911-3914.
[3] Osborne ML, Pedula KL, O'Hollaren M, et al. Assessing future need for acute care in adult asthmatics: the Profile of Asthma Risk Study: a prospective health maintenance organization-based study[J]. Chest, 2007, 132(4): 1151-1161.
[4] 中国呼吸医师协会肺功能与临床呼吸生理工作委员会, 中华医学会呼吸病学分会呼吸治疗学组. 肺功能检查报告规范——肺量计检查、支气管舒张试验、支气管激发试验[J].中华医学杂志, 2019, 99(22):1681-1691.
[5] Wanger J, Clausen JL, Coates A, et al. Standardisation of the measurement of lung volumes[J]. Eur Respir J, 2005, 26(3): 511-522.
[6] Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry[J]. Eur Respir J, 2005, 26(2): 319-338.
[7] Becker AB, Abrams EM. Asthma guidelines: the Global Initiative for Asthma in relation to national guidelines[J]. Curr Opin Allergy Clin Immunol, 2017, 17(2): 99-103.
[8] Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests[J]. Eur Respir J, 2005, 26(5): 948-968.
[9] 陈桂芝,戚良燕,邓淑仙,等.慢性持续期支气管哮喘患者焦虑、抑郁变化趋势的研究[J].中国现代医学杂志,2015, 25(31): 40-43. CHEN Guizhi, QI Liangyan, DENG Shuxian, et al. Research on the trend of anxiety and depression of patients with asthma in chromic duration[J]. China Journal of Modern Medicine, 2015, 25(31): 40-43.
[10] 刘泽英,刘双,朱晨曦,等.支气管哮喘患者支气管舒张试验指标与疗效关系的研究[J].心肺血管病杂志, 2013, 32(5): 569-572. LIU Zeying, LIU Shuang, ZHU Chenxi, et al. Study on the relationship between the bronchial relaxation test index and the curative effects in patients with bronchial asthma[J]. Journal of Cardiovascular & Pulmonary Diseases, 2013, 32(5): 569-572.
[11] 中华医学会呼吸病学分会哮喘学组.支气管哮喘患者自我管理中国专家共识[J].中华结核和呼吸杂志, 2018, 41(3): 171-178.
[12] 邢斌,林江涛,唐华平,等.我国城区支气管哮喘急性发作住院患者治疗情况的调查分析[J].中华医学杂志, 2018, 98(8): 622-626. XING Bin, LIN Jiangtao, TANG Huaping, et al. A restrospective study of the treatment of patients hospitalized for asthma exacerbation in China[J]. National Medical Journan of China, 2018, 98(8): 622-626.
[13] 林江涛,王文巧,周新,等.我国十城市支气管哮喘控制和疾病管理及患者认知水平的变化[J].中华结核和呼吸杂志, 2018, 41(3): 191-195. LIN Jiangtao, WANG Wenqiao, ZHOU Xin, et al. Trends of asthma control, disease management and perception in China[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2018, 41(3): 191-195.
[14] Reddel HK, Bateman ED, Becker A, et al. A summary of the new GINA strategy: a roadmap to asthma control[J]. Eur Respir J, 2015, 46(3): 622-639.
[15] Boulet LP, FitzGerald JM, Reddel HK. The revised 2014 GINA strategy report: opportunities for change[J]. Curr Opin Pulm Med, 2015, 21(1): 1-7.
[16] 黄传君,赵方正,陈方方,等.吸入性糖皮质激素能有效控制支气管哮喘气道炎症[J].中华结核和呼吸杂志,2018,41(11): 912.
[17] 蔡绍曦,赵海金.重症哮喘的个体化治疗现状和展望[J].中华结核和呼吸杂志, 2017, 40(11): 806-808.
[18] 刘光辉.支气管哮喘的规范化诊疗[J].医学与哲学, 2015, 36(14): 22-26. LIU Guanghui. Standardized diagnosis and treatment of bronchial asthma[J]. Medicine and Philosophy, 2015, 36(14): 22-26.
[19] 王刚,张欣,王蕾,等.轻度支气管哮喘治疗策略的商榷[J].中华结核和呼吸杂志, 2018, 41(7): 572-576.
[20] 卢慧宇,徐虹,张亚明,等.雾化吸入糖皮质激素在哮喘急性发作的应用相关问题探讨[J].中华结核和呼吸杂志, 2015, 38(2): 158-160.
[21] 沈华浩,杜旭菲,应颂敏.新版中国支气管哮喘防治指南与全球支气管哮喘防治创议的异同[J].中华结核和呼吸杂志, 2018, 41(3): 166-168.
[22] 中华医学会变态反应分会呼吸过敏学组(筹),中华医学会呼吸病学分会哮喘学组.中国过敏性哮喘诊治指南[J].中华内科杂志, 2019, 58(9): 636-655.
[23] 王远征.支气管激发试验伴发晕厥1例报告[J].江西医学院学报, 2008, 48(6): 55.
[24] 张齐武,许苏 丹,李 虹.组胺气道激发试验致严重呼吸困难 3例[J].临床肺科杂志, 2008, 13(9): 1201.
[25] 许圣慧,关继涛,高耐芬,等.成人支气管哮喘自我管理[J].国际呼吸杂志, 2017, 37(5): 383-386. XU Shenghui, GUAN Jitao, GAO Naifen, et al. Self-management of bronchial asthma in adults[J]. International Journal of Respiration, 2017, 37(5): 383-386.
[1] ZHANG Qiuping, ZHU Huizhi, LYU Chuan, XIA Yongqi, ZHANG Xiu. Identification of potential key autophagy- and ferroptosis-related genes in asthma based on bioinformatics analysis [J]. Journal of Shandong University (Health Sciences), 2026, 64(1): 74-87.
[2] ZHANG Zheng, WANG Jianwei, YANG Yujuan, ZHANG Yu, SONG Xicheng. Immunoglobulin E changes and risk factors in asthma children between 2008 and 2019 [J]. Journal of Shandong University (Health Sciences), 2025, 63(7): 32-36.
[3] CAO Luofei, WANG Shanshan, WANG Jinrong, JIANG Heyun, MIAO Yu, MA Guangzeng. Analysis of the characteristics of bronchial dilation test in children with FeNO elevation during asthma exacerbation [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 38-44.
[4] SUN Congcong, CUI Wenjing, ZHANG Jintao, ZHANG Dong, LIU Xiaofei, PAN Yun, QI Qian, XU Jiawei, ZENG Rong, GUO Hongxi, DONG Liang. Roles of ferroptosis in asthmatic airway remodeling [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 1-9.
[5] WANG Jing, LIU Xiaofei, ZENG Rong, XU Changjuan, ZHANG Jintao, DONG Liang. Identification of necroptosis-related biomarkers in asthma based on machine learning algorithms [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 21-32.
[6] YAN Jinyan, YANG Chun, LI Lei, WU Fuling, JIAO Yongli, ZHANG Xiaowei, LI Jing, ZHANG Ruizhen, WANG Lei, MA Xiang. Correlation between asthma and pertussis infection in children of Shandong Province, China [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 33-41.
[7] ZHANG Jintao, DONG Liang. Airway epithelium and epithelial-derived cytokines in asthma: reflection and outlook [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 1-6.
[8] DING Yiren, LIU Wanying, YAO Lei, YAO Xin. Research progress of the treatment of asthma with macrolide antibiotics [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 21-27.
[9] WANG Ting, ZHANG Li, WANG Gang. Neuropsychological asthma [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 28-34.
[10] XU Fang, TIAN Guoxiong, SUN Beibei, CHEN Xinyi, CHEN Gaoying, ZHANG Ruiqi, YING Songmin, WU Miaolian, ZHANG Chao, WU Youqian. Research progress on biological and cellular therapies for severe asthma [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 35-42.
[11] SHI Shuochuan, ZENG Rong, ZHANG Jintao, ZHANG Dong, PAN Yun, LIU Xiaofei, XU Changjuan, WANG Ying, DONG Liang. Bioinformatics-based exploration of potential differential immune genes and immune infiltration signatures in bronchial asthma [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 43-53.
[12] XU Xinjun, SHAO Liting, CHEN Ying, LIU Huifang, YANG Yujuan, ZHANG Yu, WANG Hanrui, SONG Xicheng. Comparison of the therapeutic effect of SYN008 with Xolair® in allergic asthma mice: inflammation and remodeling [J]. Journal of Shandong University (Health Sciences), 2024, 62(12): 1-10.
[13] HAO Yan, CUI Limei, CHEN Ying, YANG Yujuan, SONG Xicheng. Advances of metabolomics in airway inflammatory diseases [J]. Journal of Shandong University (Health Sciences), 2024, 62(12): 117-124.
[14] BU Meiling, WANG Jinrong, FENG Mei, SUN Lifeng. Mechanism of FOXM1 in acute exacerbation of asthma induced by respiratory virus infection in mice [J]. Journal of Shandong University (Health Sciences), 2023, 61(6): 1-9.
[15] ZHANG Qian, QIN Mingming, HE Xuejia, CAI Qiujing, ZHANG Yamin, LI Qingsu, ZHU Weiwei. Effects of calcitriol on EMT induced by TGF-β1 in asthma [J]. Journal of Shandong University (Health Sciences), 2021, 59(7): 10-18.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd