Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (7): 67-71.doi: 10.6040/j.issn.1671-7554.0.2019.180

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Expression and clinical significance of homo sapiens longevity assurance homologue 2 of yeast LAG1 in colorectal cancer

8.GUO Yan1, ZHANG Zheying2, WANG Yunxi1, WEI Xiaojuan1   

  1. 1. Department of Gastroenterology, Xinxiang Center Hospital, Xinxiang 453000, Henan, China;
    2. Department of Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Henan, China
  • Published:2022-09-27

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Abstract: Objective To investigate the expression and clinical significance of homo sapiens longevity assurance homologue 2 of yeast LAG1(LASS2)in colorectal cancer. Methods A total of colorectal cancer 85 cases treated during Aug. 2011 and Aug. 2013 were involved. The protein expression of LASS2 in colorectal cancer and adjacent tissues were detected with immunohistochemistry(SP method). All patients were followed up, and until Aug. 30, 2018, the complete follow-up data of 78(91.76%)cases were obtained. Patients’ survival was analyzed using Kaplan-Meier method and Log-rank test. The influencing factors on prognosis were determined with Cox proportional hazards regression model. Results The positive expression rates of LASS2 in colorectal cancer tissues and adjacent tissues was 32.94% vs 78.82%(P<0.001). The positive expression rates of LASS2 in colorectal cancer tissues with moderately poor differentiation, TNM stage Ⅲ+Ⅳ and lymph node metastasis were lower than that in high differentiation, TNM stage Ⅰ+Ⅱ and without lymph node metastasis(P<0.05). The overall survival of patients with positive versus negative LASS2 expression was 57.60 vs 28.47 months(P<0.001), and cumulative survival rate was 55.60% vs 19.60%(P<0.001). The differentiation, TNM stage, lymph node metastasis and protein expression of LASS2 were influencing factors on the 山 东 大 学 学 报 (医 学 版)57卷7期 -郭艳,等.人源性长寿保障基因2在结直肠癌组织中的表达及其临床意义 \=-prognosis(HR=0.134, 2.907, 2.478 and 0.476, P<0.05). Conclusion LASS2 is lowly expressed in colorectal cancer tissues, and is related to the malignant progression and prognosis. It might be a potential biomarker for prognosis assessment.

Key words: Colorectal cancer, Homo sapiens longevity assurance homologue 2 of yeast LAG1, Prognosis, Cox proportional hazard regression model

CLC Number: 

  • R735.3
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