Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (10): 114-118.doi: 10.6040/j.issn.1671-7554.0.2018.789

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Impacts of leptin resistance developed in boyhood on the health condition of young adults

WANG Min1, WANG Chunhua1, LIU Hongli1, HE Zhiliang2, CUI Weiwei1, WANG Lei3, LIU Jiejun1   

  1. 1. Department of General Medicine;
    2. Department of Image;
    3. Department of Cardiology, Dezhou Peoples Hospital, Dezhou 253014, Shandong, China
  • Received:2018-07-03 Online:2018-10-10 Published:2022-09-27

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Abstract: Objective To investigate the impacts of leptin resistance(LR)developed in boyhood on the health condition of young adults. Methods Subjects of a previous study conducted by us 19 years ago on the relationship between serum leptin level and early onset obesity were followed up. LR group included 9 subjects who had LR in their childhood. The normal control(NC)group consisted of 28 adults randomly selected from people with normal body mass index who came for health examination in our hospital during the same period. The control group was of the same age as LR group. Height, weight, waist circumference, blood pressure, fasting blood insulin(FINS), glucose, blood lipids, liver and kidney functions were examined in both groups. The visceral fat was determined and parents’ histories of diseases were collected in LR group. The incidence of metabolic diseases such as obesity and hypertension was compared between the two groups. Results In the LR group, the incidence of central obesity(waist circumference ≥90 cm)was 100%, visceral fat area was(209.79±55.46)cm2, index of insulin resistance(HOMA IR)was 9.42±8.00 and first-degree relatives incidence of type 2 diabetes was 100%. The systolic and diastolic pressures were significantly higher in LR group than in NC group(P=0.001 1, P=0.000 5, respectively). The levels of FBG, triglyceride(TG)and uric 山 东 大 学 学 报 (医 学 版)56卷10期 -王敏,等.男性儿童瘦素抵抗对成年后健康状况的影响 \=-acid(UA)were significantly higher in LR group than in NC group(P=0.005 0, P=0.029 8, P<0.001). The levels of glutamic-pyruvic transaminase(ALT), glutamic oxalacetic transaminase(AST)and glutamyltranspeptidase(GGT)were significantly higher in LR group than in NC group (P=0.003 1, P=0.027 1, P<0.001). The incidence of fatty liver was significantly higher in LR group than in NC group(P<0.001). Conclusion Boys with early onset obesity and LR tend to develop severe obesity and insulin resistance when they grow up. Besides, they have high risks of type 2 diabetes, dyslipidemia, cancer and liver dysfunction. LR in children can predict the risk of type 2 diabetes in the first-degree relatives.

Key words: Leptin resistance, Obesity, Insulin resistance, Male

CLC Number: 

  • R589.2
[1] Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue[J]. Nature,1994, 372(6505): 425-432.
[2] DePaoli AM. 20 years of leptin: leptin in common obesity and associated disorders of metabolism[J]. J Endocrinol, 2014, 223(1): 71-81.
[3] 王敏, 徐淑慧,刘慧, 等. 血清瘦素水平与早发肥胖关系的研究[J]. 医学综述, 2002, 8: 495-496.
[4] La Cava A, Alviggi C, Matarese G. Unraveling the multiple roles of leptin in inflammation and autoimmunity[J]. J Mol Med(Berl), 2004, 82(1): 4-11.
[5] 李光伟, 胡英华, 杨文英, 等. 胰岛素抵抗 、胰岛素分泌功能对Ⅱ型糖尿病发生的影响[J]. 中华内科杂志, 1998, 9(37): 600-604. LI Guangwei, HU Yinghua, YANG Wenying, et al. Effects of insulin resistance and insulin secretion on development of type II diabetes mellitus[J]. Chin J Intern Med, 1998, 9(37): 600-604.
[6] Lin TC, Huang KW, Liu CW, et al. Leptin signaling axis specifically associates with clinical prognosis and is multifunctional in regulating cancer progression[J]. Oncotarget, 2018, 9(24): 17210-17219.
[7] Montague CT, Prins JB, Sanders L, et al. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution[J]. Diabetes, 1997, 46(3): 342-347.
[8] Petta S, Gastaldelli A, Rebelos E, et al. Pathophysiology of non alcoholic fatty liver disease[J]. Int J Mol Sci, 2016, 17(12). pii: 2082.
[9] Çelo E, Kalari B, Toti F. A young adult with generalized lipodystrophy and diabetes mellitus(case report)[J]. Georgian Med News, 2018, 4(277): 27-31.
[10] Van Harmelen V, Reynisdottir S, Eriksson P, et al. Leptin secretion from subcutaneous and visceral adipose tissue in women[J]. Diabetes, 1998, 47(6): 913-917.
[11] Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects[J]. Nat Med, 1995, 1(11): 1155-1161.
[12] Polyzos SA, Aronis KN, Kountouras J, et al. Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis[J]. Diabetologia, 2016, 59(1): 30-43.
[13] Gastaldelli A, Cusi K, Pettiti M, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects[J]. Gastroenterology, 2007, 133(2): 496-506.
[14] 谢彦鹏, 钟锋, 肖光文. 腹型肥胖患者高尿酸血症与胰岛素抵抗的相关性研究[J]. 中国医学工程, 2014, 22(1): 25-27.
[15] 颜光涛. 瘦素有望成为诊治肿瘤的一个关键点[J]. 军医进修学院学报, 2010, 31(1): 1-3.
[16] Babińska A, Pęksa R, Swia TR, et al. Expression of adiponectin and leptin receptors in adrenal incidentaloma patients with subclinical hormone secretion[J]. Cancer Biomark, 2018. doi: 10.3233/CBM-171049(Epub ahead of print).
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