茶苯海明口腔崩解片的药代动力学研究

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (Z1): 229-230.

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Study on pharmacokinetics of dimenhydrinate orally disintegrating tablets

XU Ya-jun¹, CHU Hai-kun², WANG Nuan-feng¹, LI Min¹, LI Mei¹, WANG Yan-ju³

1. Department of Pharmacy, Daqing 163000, Heilongjiong China;
2. Department of Orthopedics and Traumatology, Daqing Oilfield General Hospital, Daqing 163000, Heilongjiong China;
3. Department of Physical Examination, Heilongjiang Provincial Hospital Nangang Branch, Haerbin 150036, China

Received:2014-11-30 Online:2014-12-30 Published:2014-12-30

Abstract

Abstract: Objective To investigate the pharmacokinetics of dimenhydrinate orally disintegrating tablets. Methods A total of 30 healthy participants were randomly divided into orally disintegrating tablets group (n=15) and normal tablets group (n=15). High performance liquid chromatography method was performed to detect the plasma concentration of dimenhydrinate. Results Time to peak(Tpeak), the Ka value, peak concentration(Cmax), lag time and area under cuive in disintegrating tablets group were different from those in normal tablet group (P<0.01). The relative bioavailability of disintegrating tablets against normal tablets was 180.12%. Conclusion The bioavailability of dimenhydrinate can be enhanced under a dosage form of orally disintegrating tablets.

Key words: Bioavailability, Dimenhydrinate, Orally disintegrating tablets

CLC Number:

R944.9

XU Ya-jun, CHU Hai-kun, WANG Nuan-feng, LI Min, LI Mei, WANG Yan-ju. Study on pharmacokinetics of dimenhydrinate orally disintegrating tablets[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(Z1): 229-230.

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