JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (S1): 18-21.

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Correlation between sensibility, and side effects of 5-FU and DPYD gene polymorphisms in periphrel blood of patients with colon cancer

WANG Yao, CHEN Yan-hong, CHEN Hong   

  1. Department of Gastroenterology, Zhong Shan City People's Hospital, Zhongshan, 528403 Guang zhou, China
  • Received:2014-11-30 Published:2014-12-30

Abstract: Objective To explore the association of 5-FU susceptibility and side effects with dihydropyrimidine dehydrogenase (DPYD) gene polymorphism in colon cancer patients. Methods A total of 100 colon cancer patients were recruited and treated with FOLFOX4 regimen. Quantitative PCR were taken to measure DPYD gene polymorphism at loci 14G1A, A1627G, T85C3. Relationship between susceptibility and side effects of 5-FU and gene polymorphism were analyzed .Results 14G1A A1627G, T85C were detected with site mutation, with 14% , 11% and 17% of mutant frequencies , respectively .The susceptibility to 5-FU in mutant gene were significantly lower than those in wild-type gene (P<0.05). Adverse reaction rate such as bone marrow inhibition, hand-foot syndrome, diarrhea, gastrointestinal reactions was significantly higher in mutant gene than that of wild-type genes (P<0.05). Conclusion DPYD gene polymorphism may be useful in predicting side reaction of 5-FU.

Key words: 5-fluorouracil, Dihydropyrimidine dehydrogenase, Colon cancer, Gene polymorphism

CLC Number: 

  • R394
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