Abstract:

Objective  To perform dynamic observation of the restoration of renal function at different time points after re-canalization of ureteral obstruction. Methods  Twentyfour dogs were randomly divided into 3 groups to produce the ureteral obstruction model by ligation of the left ureter. The ureteral recanalization was done 1, 4, or 8 weeks after the ligation, and radionuclide（99mTc-DTPA）scanning was carried out before or after obstruction and the two weeks or four months after recanalization. Changes of images of the restoration of renal function were observed and glomerular filtration rate(GFR) was calculated. Results  The renal function in dogs that received re-canalization 1 week after ureteral obstruction was fully restored to normal level; renal function in dogs of 4 weeks obstruction was only partially restored after re-canalization; no restoration of renal function was observed in dogs that received re-canalization 8 weeks after obstruction. Conclusions  Duration of the ureteral obstruction is the key factor affecting the recovery of renal function in dogs. The better restoration of renal function depends on early ureteral recanalization.

Key words: Ureteral obstruction; Renal function; Dogs