Abstract:

Objective  To observe the effect of daunorubicin and cytarabine chemotherapy on islet-cell dysfunction. Methods  27 patients with acute non-lymphocyte leukemia (ANLL) were selected and accepted standard DA (daunorubicin+Cytarabine) chemotherapy for two cycles. Before and after the chemotherapy, an insulin release test, the blood sugar average value, insulin average value, area under the blood sugar curve, area under the insulin curve and exponential functions of islet β-cells were determined. Results  After chemotherapy, blood glucose curve points increased at each time point, especially at points of an empty stomach, half an hour and 1 hour (P<0、05); the area under the blood sugar curve aggrandized significantly (P<0、05); the area under the insulin curve was obviously reduced (P<0、05); and the exponential of β-cell functions decreased. Conclusion  Daunorubicin and cytarabine do certain damage to the functions of islet β-cells in patients who suffer from leucocythemia without diabetes, and may cause diabetes.

Key words: Daunorubicin; Islet βcells; Diabetes;  Leukemia,  nonlymphocytic, acute