Abstract:

Objective  To investigate the effects of hemodilution combined with preemptive analgesia on haemodynamics in free tissue graft. Methods  160 patients whose anticus tibialis soft tissue was lost and was repaired with a thigh anterolateral flap were randomly placed into 4 groups: the hemodilution combined with preemptive analgesia group (group A), the hemodilution group(group B), the preemptive analgesia group(group C) and the control group(group D). Plt, corticosteroid, serum norepinephrine, APTT and PT were detected perioperatively. The relationship between survival rate and blood vessel crisis of flap was observed. Results  There was no significant difference in the above indexes among the 4 groups preoperatively. Corticosteroid, serum norepinephrine, APTT and PT were significantly increased after operation in group B and group D.  PLT and PT were significantly increased after operation in group C. The incidence of blood vessel crisis was 2.5% in group A, 7.5% in group B, 2.5%  in group C and 10% in group D. Survival rate of the flap was 100% in group A, 95% in group B, 97.5%  in group C and 92.5% in group D. Conclusion  Hemodilution combined with preemptive analgesia can significantly improve the blood circulation and survival rate of the grafted tissue.

Key words: Hemodilution; Tissue graft; Blood circulation; Hypercoagulability; Norepinephrine