Abstract:

Objective To investigate the effect of the Yiqi Huoxue decoction on CTGF and PDGF-B of chronic renal failure(CRF) rats．  Methods Rat models of CRF were established by feeding Adenine．All the rats were randomly divided into six groups：the normal group， the model group， the high dosage Yiqi Huoxue decoction group， the medium dosage Yiqi Huoxue decoction group，  the low dosage Yiqi Huoxue decoction group and the losartan group． After 8 weeks，  levels of serum creatinine(SCr)，  blood urea nitrogen(BUN)，  triglyceride(TG)，  cholesterol(CHO)， plasma albumin(ALB)， and hemoglobin(HB) were determined． In addition， the results of pathology were found by HE and the expressions of CTGF and PDGF-B were determined by the immuohistochemical method．   Results   Compared with the model group， levels ofSCr,  BUN,  and CHO in the Yiqi Huoxue decoction groups and the losartan group were decreased,  while levels of ALB and HB were increased (P<0.05)．Pathological results of the Yiqi Huoxue decoction groups and the losartan group were betterthan those of the model group， and those of the high dosage Yiqi Huoxue decoction group were the best． Expressions of CTGF and PDGF-B in the Yiqi Huoxue decoction groups and the losartan group were decreased compared with the model group.  Conclusions   Yiqi Huoxue decoction can efficiently decrease SCr， BUN， and CHO levels and increase ALB and HB levels， reduce pathological injury and the CTGF and  PDGF-B expressions， and postpone the aggravation of renal function．