JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effects of radix salvia miltiorrhiz on TNFαand IL1 during
cold ischemia and reperfusion injury in rat
orthotopic liver transplantation

WANG Yu1, ZHOU Jie1, JIANG Xiaoqing2
   

  1. （1. Department of Hepatobiliary Surgery； 2. Department of Anesthesia, Nanfang Hospital of
    South Medical University, Guangzhou 510515, China）
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16

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Abstract: To investigate the effect of radix salvia miltiorrhiz on TNFαand IL1 of the donor liver during orthotopic liver transplantation. Methods40 SD male rats were randomly divided into the experimental group, the control group and the sham operation group. Perfusing and preserving solution were miltiorrhiz Ringer′s lactate solution in the experimental group and Ringer′s lactate solution without miltiorrhiz in the control group. All grafts were preserved for 5 hours and then were orthotopically transplanted. Six hours after reperfusion, the recipients were sacrificed, and the serum ALT and AST were measured. Also, changes of oxygenderived free radical level MDA and expressions of TNFαand IL1 in the liver were determined. The histopathological changes were observed under a light microscope. ResultsSerum ALT and AST levels in the experimental group were significantly lower than those in the control group after reperfusion. MDA, TNFαand IL1 levels were lower in the experimental group than those in the control group. Histopathological injury changes were not as serious as in the control group. ConclusionRadix salvia miltiorrhiz may decrease the levels of TNFαand IL1 to prevent the liver graft ischemia reperfusion injury in orthotopic liver transplantation in rats.

Key words: Radix salvia miltiorrhiz, Liver transplantation, Ischemia reperfusion injury, Rat,SpragueDawley, Tumor necrosis factoralpha, Interleukin

CLC Number: 

  • R657.3
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