JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• 无栏目 • Previous Articles     Next Articles

A rat model for studying water and sodium metabolism following cervical spinal cord injury

LIU Yang, JIA Tanghong, GONG Weiming, NING Bin, GUO Shuya,
SONG Hongliang, XU Peng, ZHANG Tao, ZHANG Laibo
  

  1. (Department of Orthopaedics, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-03-16 Published:2009-03-16
  • Contact: JIA Tanghong

PDF (PC)

291

Abstract: To establish a rat model of cervical spinal cord injury(SCI) for exploring the mechanism of metabolic disturbance of water and sodium after cervical SCI. MethodsFortyfive female adult Wistar rats were randomly divided into three groups: fifteen in group A were fed with normal rodent food without surgeries (the control group), fifteen in group B were fed with enteral nutritional emulsion(TP) and subjected to gastrostomy after lesions of the paravertebral muscles (the sham group), and fifteen in group C were fed with TP and subjected to gastrostomy after cervical spinal cord transaction (SCT) and urethral catheterization (the experimental group). The urine volume and concentration of sodium in blood and urine were determined. ResultsCompared with group B, group C had hyponatremia four days after the operations (P<0.05). Blood sodium concentration was not obviously different between group A and groups B and C preoperatively（P＞0.05）. ConclusionHyponatremia happens after cervical spinal cord injury in rats.

Key words: Spinal cord injury, Metabolism, Models,animal, Rats,Wistar

CLC Number: 

  • Ｒ681.5
[1] ZHAO Xiangrui, YIN Yongcheng, FANG Yuepeng, YANG Zhijie, NING Bin. Role and mechanism of matrix Gla protein in fibrotic scar formation after spinal cord injury [J]. Journal of Shandong University (Health Sciences), 2026, 64(5): 50-60.
[2] LI Xiping, QIU Mei, HUANG Ruifeng, LIN Huihui, LIU Sisi, LUO Hongying, WANG Yuyue, WANG Min, YANG Xiaotong. Research progress on the mechanism of berberines anti-atherosclerosis effects based on the synergistic effect of lipid deposition inhibition and metabolic clearance [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 77-83.
[3] LIU Xiang, GAO Wei, WANG Chao, ZHANG Xiaoyan. Visual analysis of rehabilitation research on patients with paraplegia caused by spinal cord injury based on Web of Science [J]. Journal of Shandong University (Health Sciences), 2025, 63(11): 75-86.
[4] ZHOU Yongkang, SUN Jing, ZHANG Shuai, QIAN Xiangyang. Progress in spinal cord protection strategies for open repair of thoracoabdominal aortic aneurysms [J]. Journal of Shandong University (Health Sciences), 2024, 62(9): 49-54.
[5] SUN Jing, ZHANG Shuai, QI Hongxia, LI Yuan, ZHOU Yongkang, HU Kejian, QIAN Xiangyang. Spinal cord protection by normothermic auto-arterial bypass and distal-anastomosis-first strategy in thoracoabdominal aortic replacement surgery [J]. Journal of Shandong University (Health Sciences), 2024, 62(9): 80-85.
[6] WANG Rui, YU Kang, LIU Yanping. Research advances in Vitamin K2 and pregnancy-related diseases [J]. Journal of Shandong University (Health Sciences), 2024, 62(8): 9-17.
[7] LIU Haixia, HUANGFU Shasha, SANG Xiaoyu, CUI Dongqing, BI Jianzhong, WANG Ping. Effects of mesenchymal stem cells on ferroptosis in experimental autoimmune encephalomyelitis mice [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 1-8.
[8] ZHAO Zhibo, MAN Zhentao, LI Wei. Role of cholesterol metabolism in osteoarthritis: a review of research progresses [J]. Journal of Shandong University (Health Sciences), 2024, 62(2): 1-9.
[9] WANG Zan, XU Xiaohan, ZHANG Yu, QU Yemin, WANG Mingyi, CHEN Ai. Effects of Helicobacter pylori infection on glycolysis of gastric cancer cells [J]. Journal of Shandong University (Health Sciences), 2023, 61(2): 16-24.
[10] LU Xingchen, QIANG Ye, LIU Xinyu, ZUO Dan, JIANG Zihan, ZHANG Yuchao, LIU Yuantao, MA Xiaoli. Effects of NR4A1 on thapsigargin-induced glucose metabolism dysfunction in C2C12 myotube cells [J]. Journal of Shandong University (Health Sciences), 2023, 61(11): 38-47.
[11] HU Yanwen, WANG Zhiyuan, YU Wanjiang, ZHAO Huichen, HAN Heli, XU Zhipeng, MA Hong, ZHANG Yuchao, LIU Yuantao. Correlation of fat distribution with metabolic syndrome and glucose metabolism in 52 obese patients [J]. Journal of Shandong University (Health Sciences), 2020, 1(8): 101-106.
[12] LI Yan, SUN Fengjiao, ZHANG Tianran, WANG Yuxin, ZHANG Zhengduo, GAO Xibao. Effects of high-sugar, high-fat diet and different concentrations of selenium on lipid metabolism and oxidative stress in rats [J]. Journal of Shandong University (Health Sciences), 2020, 58(5): 98-106.
[13] SUN Fengjiao, LI Yan, WANG Yuxin, ZHANG Tianran, WU Hong, GAO Xibao. Effects of dietary structure and selenium concentration on glucose metabolism in rats [J]. Journal of Shandong University (Health Sciences), 2020, 58(2): 36-43.
[14] LIU Yuanyuan, WANG Pei, CHU Haichen. Effects of different anesthesia depths on the cerebral oxygen metabolism indexes in 150 patients undergoing brain surgery [J]. Journal of Shandong University (Health Sciences), 2020, 58(12): 65-71.
[15] JIANG Lijuan, LIU Fuqiang, JIANG Ziyun, LI Wenjuan, LIN Peng, WANG Chuan, HOU Xinguo, CHEN Li. Dapagliflozin improves lipid metabolism and visceral adipose tissues in overweight and obese patients with type 2 diabetes [J]. Journal of Shandong University (Health Sciences), 2019, 57(6): 87-93.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd