JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Genetic polymorphism of thrombinactivatable fibrinolysis inhibitor (TAFI)
associated with type 2 diabetes mellitus

WU Xiaoben1，　XU Chengwei1，　SUN Fudun2,　ZHAO Jingjie3，　WANG Lili1, WANG Zejun1
   

  1. （1. Department of Laboratory Medicine; 2. Department of Endocrinology;
    3. Laboratory of Clinical Molecular Biology， Second Hospital of Shandong University, Jinan 250033, China）
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-02-16 Published:2009-02-16
  • Contact: XU Chengwei

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Abstract: To investigate the possible association of the TAFI activityrelated two polymorphisms (505A/G, 1040C/T) with type 2 diabetes mellitus (T2DM). MethodsFrequencies of the 505A/G and 1?040C/T polymorphisms resulted in two amino acid substitutions: Ala for Thr at position 147 and Ile for Thr at position 325 in 157 T2DM patients and 140 healthy controls by using the polymerase chain reactionrestriction fragment length polymorphism(PCRRFLP) typing analysis method. ResultsNo significant differences of the TAFI levels appeared between patients and controls at 505A/G. At 1040C/T, frequency for the T allele in the patient group was significantly lower than that in the control group (15.6% versus 25.7%, P＜0.05), which was due to the relative decrease of T/T homozygotes in the patient group (P＜0.05, 95% OR 0.28,CI 0.110.70). The same pattern of significance was also observed between controls and subgroups of patients with initial stages of T2DM categorized by the urine albumin excretion (UAE μg/mL)tocreatinine (mg/mL) ratios (ACRs). Conclusion① At 1?040C/T the frequency for the T allele is strongly associated with T2DM in a subset of the general population. ② The T allele confers protection against the onset of T2DM only in homozygosity and may serve as a recessive trait.

Key words: Diabetes mellitus,noninsulindependent, Thrombinactivatable fibrinolysis inhibitor, Polymorphism

CLC Number: 

  • R587．1
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