JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of GPⅡb/Ⅲa, PSelectin and vWF in children with HenochSchonlein purpura

ZHANG Hongxia1, LIU Xuemei2, LIU Fange1, LIN Aiwei2，　DUAN Chunhong2，　YANG Xiaomei2
   

  1. (1. Department of Pediatrics, Second Hospital of Shandong University, Jinan 250033, China; 2. Qilu Children′s Hospital of Shandong University， Jinan 250022, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-01-16 Published:2009-01-16
  • Contact: LIU Fange

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Abstract: To investigate the role of platelet membrane glycoproteinⅡb/Ⅲa, Pselectin and von Willebrane Factor in children with HenochSchonlein purpura (HSP), and to investigate the pathological role of them in HSP. MethodsThe concentrations of CD41a/CD61 and CD62P were determined by flow cytometry and the level of vWF by an enzymelinked immunosorbent assay(ELISA) method in 44 patients with acute HSP, 40 patients in the recovery phase and 18 healthy controls. ResultsThe plasma levels of CD41a/CD61, CD62P and vWF in the acute phase were significantly higher than those in the recovery phase, were higher than those in healthy controls(P<0.01), and also were higher in the renal damage group than in the nonrenal damage group(P<0.01). ConclusionActivation of platelet and damage of vascular endothelium play important roles in the pathological mechanism of HSP. Levels of CD41a/CD61, CD62P and vWF are helpful in finding the disturbance of blood coagulation，and provide a basis for anticoagulant treatments.

Key words: Purpura,HenochSchonlein, Platelet membrane glycoproteins, Pselectin, von Willebrane factor, Child

CLC Number: 

  • R725.9
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