Abstract:

Objective〓〖WTBZ〗To explore the effects of Ringer′s solution and Synvisc in treatment of knee osteoarthritis(OA). 〖WTHZ〗Methods〓〖WTBZ〗A total 58 outpatients with knee osteoarthritis were randomly divided into three groups. Group A accepted simple intra-articular irrigation of Ringer′s solution, group B accepted simple Synvisc injection and group C accepted both intra-articular irrigation of Ringer′s solution and Synvisc injection. Westem Ontario and McMaster University Osteoarthritis Index (WOMAC) pain score were used to assess the effects before treatment and[JP2]1, 8, 12, 24 and 52 weeks after treatment. All treatments were finished by the sam doctor group in the Qingdao Municipal Hospital by a patient-blinded method. All analyses were performed by the Stata software. 〖WTHZ〗Results〓〖WTBZ〗All three groups had the WOMAC pain scores significantly[JP2] improved at 8, 12 and 24 weeks(P＜0.05), and groups B and C still had significant effects at 52 weeks (P＜0.05). Groups B and C were superior to group A in clinical efficacy(P＜0.05), and group C was superior to group B in pain relief at 1-week term(P＜0.05). 〖JP2〗〖WTHZ〗Conclusions〓〖WTBZ〗Either Ringer′s solution or Synvisc injection can significantly improve the WOMAC pain scores for knee osteoarthritis, and Synvisc injection is superior to Ringer′s solution in pain-relief, duration and operative briefness， but there are no folded effects when they are used in combination.

Key words: Osteoarthritis, Intra-articular perfusion, Synvisc