JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of Prostaglandin E1 on renal hemodynamics in patients with diabetic nephropathy

XIN Ying1，　DONG Jian-jun2，　PANG Shu-guang1，　QU Yong1，　LIAO Lin1

  

  1. 1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;2. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China

  • Received:1900-01-01 Revised:1900-01-01 Online:2008-07-16 Published:2008-07-16
  • Contact: LIAO Lin

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Abstract:

Objective〓〖WTBZ〗To explore changes of renal hemodynamics in type 2 diabetes with diabetic nephropathy before and after treatment with PGE1. 〖WTHZ〗Method〓〖WTBZ〗Diabetic patients were divided into two groups: the conventional treatment group and the conventional plus PGE1 treatment group. Blood flow of the renal artery in patients with type 2 diabetes mellitus was determined by using Doppler color flow imaging before and after treatment. 〖WTHZ〗Results〓〖WTBZ〗① In patients with diabetic nephropathy(Ⅲ, Ⅳ and Ⅴ), the Vsmax, Vdmin and Q levels were significantly higher in the PGE1 group than in the conventional group（P＜0.01）, and the RI level was lower in the PGE1 group than in the conventional group（P＜0.01）. ② The response was the best in stage Ⅲ (P＜0.01）and the PGE1 group was better than the conventional group（P＜0.01）. 〖WTHZ〗Conclusion〓〖WTBZ〗PGE1 is effect in improving renal hemodynamics and the earlier the treatment acts, the better the response.

Key words: Prostaglandins E, Kidney, Hemodynamics, Diabetic nephropathies

CLC Number: 

  • R445.1
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