JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Effect of zeaxanthin on retinal pigment epithelium cells damage induced by hypoxia

PEI Ling-peng   

  1. Research Center of Minarity Traditional Medicine, Central University for Nationalities, Beijing 100081, China

  • Received:1900-01-01 Revised:1900-01-01 Online:2008-07-16 Published:2008-07-16
  • Contact: PEI Ling-peng

PDF (PC)

420

Abstract:

Objective〓〖WTBZ〗To investigate the effect of zeaxanthin on damage of retinal pigment epithelium cells induced by hypoxia. 〖WTHZ〗Methods〓〖WTBZ〗ARPE19 cells were randomly divided into five groups: the control group，the hypoxia model group (95% N2 and 5% CO2, O2＜1%), the low dose (1×10-8mol·L-1) zeaxanthin group, the middle dose (1×10-7mol·L-1 zeaxanthin group and the high dose (1×10-6mol·L-1) zeaxanthin group. Cell activity, superoxide dismutase (SOD) activity, and the contents of reactive oxygen species (ROS) and lipid oxygen (LPO) were determined. 〖WTHZ〗Results〓〖WTBZ〗 Compared with the hypoxia model group， cell activity and SOD activity in the zeaxanthin groups were significantly increased (P＜0.01). However, the contents of ROS and LPO were significantly decreased（P＜0.01）. 〖WTHZ〗Conclusion〓〖WTBZ〗Zeaxanthin can decrease the influence of active oxygen and protects retinal pigment epithelium cells against damage.

Key words: Zeaxanthin, Retinal pigment epithelium cell, Reactive oxygen species, Lipid oxygen, Superoxide dismutase

CLC Number: 

  • R965
[1] CHEN Yang, FENG Ying, LU Xiao, ZHENG Rong. Galectin-3 promotes autophagy and polarization of macrophages via the PI3K/Akt/mTOR pathway [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 14-22.
[2] LIU Fengqi, GAO Feng, XUE Caicai, QIAO Xiumei, WANG Jinhong. Influencing factors of PC12 cell injury induced by high glucose and the protective effects of catalpol [J]. Journal of Shandong University (Health Sciences), 2023, 61(7): 34-39.
[3] BAO Shuqing, YANG Mingyue, LIU Duanrui, WANG Yunshan, JIA Yanfei. Role of NOX4 in ROS induction by Helicobacter pylori in gastric cancer cells [J]. Journal of Shandong University (Health Sciences), 2022, 60(6): 19-25.
[4] LI Minqi, DU Juan, YANG Panpan, KOU Yuying, LIU Shanshan. Research progress of oxidative stress regulating osteoporosis [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 16-24.
[5] ZHAO Zuohui, LI Cuiling, WANG Daoguang, WANG Fengqin, QU Hongyi, DING Sentai, GONG Jing, LÜ Jiaju, YANG Jinghua. Effect of MnSOD acetylation on the proliferation and apoptosis of clear cell renal cell carcinoma cell line 786-O [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 31-35.
[6] LI Shuai, WANG Yalin, SUN Zhongwen, ZHU Meijia. Expression changes and mechanism of Nod-like receptor protein 3 inflammasome in the cerebral microvascular endothelial cells in type 2 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 6-11.
[7] WANG Xue, LI Qian, WANG Li, SUN Shuzhen, MA Aihua. CXCL16 gene silencing alleviates injury of mouse podocytes treated with the oxidized low-density lipoprotein [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 16-21.
[8] LIU Hui, CHEN Tongshuai, LI Na, WANG Shujian, LI Jingyuan, BU Peili. Role of Sirt3 on the senescence of human umbilical vein endothelial cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 41-45.
[9] YANG Lu, ZHOU Yingze, NI Ming, FAN Xiushuang, MAN Jianmei, GUO Juntang. Beta-synuclein promotes the expression of vesicular monoamine transporter-2 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(4): 61-64.
[10] QIU Zongjian, YANG Juan, SONG Qiang. Role of decitabine in the mitochondria biogenesis of synchronized G0/G1 phase MDS-L cell line [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(5): 5-9.
[11] SUN Gao-ying1, WANG Xiao-yuan2, ZHANG Xiao-jin1, HAO Xiu-yu1， GUO Yuan-fang1, WANG Xiao1, BI Wen-xiang1. Effects of N-acetylcysteine  on resistance to paclitaxel in cervical carcinoma cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(3): 42-47.
[12] JIANG Chong-hui1, AI Xiao-hong2, YANG Xiao-hong3, LUO Qiong3, CAO Jian-guo3. Generation of reactive oxygen species in apoptosis of human gastric cancer
SGC-7901 cells induced by 5,7-Dihydroxy-8-nitrochrysin [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 34-37.
[13] DONG Chuan-fang1, LIU Xue-ping1, WANG Mei-xia1, XU Song1, YIN Qin-qing1, SUN Zhi-jian1, YOU Li2. Effect of advanced glycation end products on oxidative stress andapoptosis of SH-SY5Y cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(1): 9-.
[14] ZHU Wei1,2， PAN Fang1， JIANG Hong1， YU Hong-luan1， SUN Lin1， WANG Li1. Effects of ketamine on cerebrovascular pathology and NADPH oxidase activation in cynomolgus monkeys [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 47-51.
[15] YIN Hai-qin1, WEI Yu-ping2, WANG Xiao-yuan3， PENG Nan1, BI Wen-xiang2, KONG Feng2, ZHANG Pei-hai1. Comparison of antioxidant abilities of cervical squamous  carcinoma and adenocarcinoma cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(3): 55-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd