JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Association between two concurrent gene polymorphisms and type 2 diabetes with macro-angiopathy

ZOU Cai-yan1, LI Yin-yin1,　LI Qiu1,　CHEN Han-yan1,　WANG Lai-cheng2,　LV Xiao-xia2   

  1. 1. Department of Health Care Eendocrine; 2. Department of Scientific Research, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2008-01-08 Revised:1900-01-01 Online:2008-06-16 Published:2008-06-16
  • Contact: LI Yin-yin

PDF (PC)

495

Abstract: To investigate the correlation between polymorphisms of both +299G/A at resistin gene and Pro12Ala at PPARγ2 gene and diabetic macro-angiopathy. MethodGenotypes and alleles of polymorphisms of both genes were determined with polymerase chain reactionrestriction fragment length polymorphism assay (PCRRFLP) of 296 subjects in Han Chinese. Results Both resistin gene +299G/A alleles frequencies in group A (the type 2 diabetes group) and alleles frequencies and genotypes in group B(the type 2 diabetes combined with the macroangiopathy group) were statistically significant from those in the control group(P＜0.05), but P/A alleles frequencies and genotypes to of the PPARγ2 gene were statistically different in groups A (P＞0.05 vs the control group) and were statistically different in group B (P＜0.05 vs the control and the A group). Type 2 diabetes with the coexistence of the A allele/AA genotype of resistin gene and the A allele/PA genotype of the PPARγ2 gene had a lower incidence of macro-angiopathy than those with one gene alone or without the gene(P＜0.05). ConclusionThe A allele/AA genotype at resistin gene of +299 and the Ala allele at the PPARγ2 gene of Pro12Ala are related to diabetic macroangiopathy.

Key words: Diabetes mellitus, non-insulin-dependent, Vascular diseases, Resistin, Polymorphism, single nucleotide

CLC Number: 

  • R587.1
[1] GE Li-Juan, JIN Rui-Feng, WANG Ji-Wen, HU Xin-Sheng, LIKun. Association between the C1236T polymorphism in multi-drug resistance gene 1 and response to antiepileptic drug treatment in epileptic patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 99-102.
[2] MENG Xiaomei, HAO Yaping, WANG Liang, YU Xiao, TANG Yuxiao. Correlation between the levels of serum Isthmin1, Gremlin2 and retinopathy in type 2 diabetic patients [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 102-107.
[3] WANG Mengxing, XUE Fuzhong, YANG Fan. Blood glucose concentration prediction method for type 1 diabetes mellitus based on multi-modal cross-attention mechanism fusion [J]. Journal of Shandong University (Health Sciences), 2025, 63(8): 41-50.
[4] SHEN Lujia, LU Tianwei, GONG Weiming, ZHAO Yansong, WANG Shukang, YUAN Zhongshang. Application of metabolomic risk score in predicting cardiovascular outcomes in patients with type 2 diabetes mellitus [J]. Journal of Shandong University (Health Sciences), 2025, 63(8): 69-78.
[5] CHEN Yingying, WANG Lu, HU Xifeng, ZHU Gaopei, XUE Fuzhong. A Bayesian network-based risk prediction study of stroke in patients with type 2 diabetes mellitus [J]. Journal of Shandong University (Health Sciences), 2025, 63(8): 94-102.
[6] CHEN Xujun, HE Guowei. Focus on further more use of arterial grafts in coronary artery bypass grafting in patients with coronary heart disease in China [J]. Journal of Shandong University (Health Sciences), 2025, 63(5): 1-5.
[7] LU Shengxun, XING Yachuang, LUO Junhui, LIU Jie, HE Houle, WANG Zhiqiang, ZHANG Na. Diabetic patients arterial grafts in coronary artery bypass grafting: current research status [J]. Journal of Shandong University (Health Sciences), 2025, 63(5): 33-39.
[8] HOU Xiaohui, AREZOU Bikdeli, MA Chao, LI Daqing. Correlation analysis of combining ACE, KLK1 and PTGIS genotypes among 250 NSTE-ACS patients [J]. Journal of Shandong University (Health Sciences), 2025, 63(2): 10-20.
[9] DU Kaihao, HOU Lizhao, DONG Xiaoge, XUE Weiwei, HE Jiejie, LUO Lanminghui, JIANG Wei, WANG Zhanjin, WANG Zhan. Relationship between gut microbiota and pancreatic cancer in East Asians: genetic evidence based on Mendelian randomization [J]. Journal of Shandong University (Health Sciences), 2025, 63(12): 44-52.
[10] YANG Chuntao, ZUO Yu. Causal relationship of MMP1 and MMP9 genes with chronic periodontitis: an exploratory study based on two-sample Mendelian randomization [J]. Journal of Shandong University (Health Sciences), 2025, 63(11): 87-97.
[11] LIN Xiaoqian, FENG Maoyan, MOU Zheng. Pharmaceutical characteristics and clinical utility of dipeptidyl peptidase-4 inhibitors [J]. Journal of Shandong University (Health Sciences), 2024, 62(12): 43-48.
[12] YU Qingqing, CHANG Kaifeng, LI Jiqing, ZHANG Kai, FU Ping,LIU Xiaowen, ZHAO Yingqi, XUE Fuzhong. Mediation effects of hypertension on the association between exposure to non-steroidal anti-inflammatory drugs and risk of cardio-cerebrovascular diseases in middle-aged and elderly people [J]. Journal of Shandong University (Health Sciences), 2023, 61(8): 79-85.
[13] LI Jinquan, GAO Meifang, YAN Fei, DONG Ming. Frequency and risk factors of muscle cramp in 136 cases of type 2 diabetes mellitus [J]. Journal of Shandong University (Health Sciences), 2023, 61(5): 20-24.
[14] HAN Mei, MENG Weijing, TAO Zikun, YANG Xi, XU Yaqi, MU Huaxia, BU Weixiao, WANG Suzhen, SHI Fuyan. Causal mediation analysis with multiple-mediator of hypertension and depression between type 2 diabetes mellitus and cognitive function based on G-computation [J]. Journal of Shandong University (Health Sciences), 2023, 61(10): 101-108.
[15] LI Tao, YANG Chunlin, DU Tong, LI Heng, WANG Congcong, LI Xiaoli, DUAN Ruisheng,ZHANG Peng. Effects of diabetes mellitus on the subsets and function of NK cells in myasthenia gravis [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 31-36.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd