JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Relationship between XRCC3 gene polymorphism and bladder cancer in the Han population

HAO Gang-yue1， ZHANG Yue-ying2, ZHANG Wei-dong2, YANG Ming-shan3, JIA Qing2   

  1. 1. Department of Urology, Beijing Friendship Hospital, Capital Medical University；2. Institute of Basic Medicine, Shandong Academy of Medical Science, Key Laboratory for Modern Medicine and Technology of Shandong Province
  • Received:2007-11-13 Revised:1900-01-01 Online:2008-06-16 Published:2008-06-16
  • Contact: HAO Gang-yue

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Abstract: To investigate the relationship between polymorphisms of DNA repair gene XRCC3 and the risk and clinical outcome of bladder cancer. Methods In a hospital based case-control study for the Chinese population, a total of 307 bladder cancer cases and 316 age- and sex-matched controls with urological non-neoplastic diseases were collected. We analyzed the genotypes of XRCC3 (Thr241Met) by PCR-RFLP and determined their association with bladder cancer risk and clinical outcome. ResultsThe frequency of Thr/Thr, Thr/Met and Met/Met genotype was 87.3%, 12.1% and 0. 6% in cases and was 92.4%, 7.3% and 0.3% in controls. When Thr/Thr served as the reference group, variant genotypes (Thr/Met and Met/Met) had a significant increased risk of bladder cancer（OR, 1.77；95%CI, 1.04-3.02）. Combined with smoking and clinical types, no significant interaction could be found. However, the variant genotypes were associated with an increase of recurrence risk among superficial bladder cancer(OR，3.08；95%CI，1.13-8.41). Conclusions XRCC3 gene polymorphism may be a risk factor for bladder cancer and it may serve as a molecular marker for monitoring bladder cancer recurrence.

Key words: Polymorphism, restriction fragment length, Bladder neoplasms, Recurrence, X-ray repair crosscomplementing gene 3

CLC Number: 

  • R737.14
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