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CK5／6 expression in human breast cancer with tissue micro-array and its clinical significance

BI Xiao-feng, GAO Ji-dong, XUAN Li-xue, ZHANG Bao-ning   

  1. Department of Surgical Oncology, Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100021, China
  • Received:2008-03-12 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: ZHANG Bao-ning

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Abstract: To explore the expression of CK5／6 in breast cancer. MethodsThe expression of CK5／6 in 240 breast carcinomas samples was determined by immunohistochemistry with tissue microarray (TMA). ResultsPositive expression ratio of CK5／6 in breast cancer was 14.72％(29／197). CK5／6 expression was not correlated with age, menses, size of tumor, clinical TNM stage, auxiliary lymph nodes metastasis, or pathologic type(P>005)but was correlated with negative expression of ER; Patients with negative CK5／6 expression survived longer than those with positive expression(P<001). Conclusions Positive expression of CK5／6 can result in poor prognosis and it may be one of markers to evaluate the prognosis of breast cancer.

Key words: Breast carcinoma, Tissue microarray, Immunohistochemistry, CK5／6

CLC Number: 

  • R735.8
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