JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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The MAGE-3-sensitized dendritic cell vaccine kills bladder cancer cells in vitro

MA Ming 1,2, LI Xiu-zhen3, WANG Chao1, GUO Hong-min2, MA Xin1, ZHANG Xu1   

  1. 1. Department of Urology, Tongji Hospital,Huazhong University of Science and Technology, Wuhan 470030, China;2. Department of Urology, Jining First People′s Hospital, Jining 272011, China;3. Department of Microbiology, Jining Medical College, Jining 272011, Shandong, China
  • Received:2008-01-17 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: ZHANG Xu

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Abstract: To explore the cytotoxic activity of cytotoxicity T lymphocyte (CTL) induced by MAGE-3-sensitized dendritic cells (DCs) on the bladder cancer cell line BIU-87. MethodsProliferation of T cells and cytotoxic activity of CTL were determined by the MTT method. CTL was induced by MAGE-3-sensitized DC cells, and ovalbumin (OVA) peptide and un-sensitized DC served as controls. ResultsThe MAGE-3-sensitized DC could promote proliferation of T cells and cytotoxity activity of the CTL cells on bladder cancer cells as compared with OVA peptide or unsensitized DC. ConclusionDC sensitized by the MAGE-3 antigen peptide can promote multiplication of T cells and can develop a cell immunity function, it also inhibits the growth of tumor and accelerates tumor decline. It can be used as a novel vaccine on bladder cancer therapy.

Key words: Bladder neoplasms, Dendritic cells, Antigen, Peptides, MAGE-3 Gens

CLC Number: 

  • R737.14
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