JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effects of propofol on whole body hyperthermia-induced Caspase-3 expression and ultra-structure changes of the hippocampus in rats

BU Xiang-mei1, ZHAO Xin2,　WANG Zhi-gang2, WANG Duan-yu1   

  1. 1. School of Medicine, Shandong University, Jinan 250012, China; 2. Department of Anesthesiology, Second Hospital of Shandong University, Jinan 250033, China
  • Received:2007-12-13 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: BU Xiang-mei

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Abstract: To explore the effects of propofol on whole body hyperthermia(WBH)-induced Caspase-3 expression and ultra-structure changes of the hippocampus in rats. MethodsSixty-three male Wister rats weighed 300-350g were randomly divided into 3 groups(n＝21 in each): the control group(A), the WBH anesthetized with Chloral Hydrate group(B), and the WBH anesthetized with 150mg/kg propofol group (C). Twenty rats′ brains in each group were removed for determination of Caspase-3 expression by using the SABC immuno-histochemical technique, and one rat′s brain in each group was isolated for electron microscopic examination of hippocampal neurons. ResultsThere was no expression of Caspase-3 in group A. The expression of Caspase-3 in group C was decreased compared with that in group B（P＜0.01). In groups B and C, expansion and vacuolization of mitochondria, swollen neurons and apoptotic bodies appeared, which suggested that WBH could induce neuron injury, and the neuron injury in group C was more severe than that in group B. ConclusionPropofol could decrease the expression of Caspase-3 and ultra-structure damage induced by WBH.

Key words: Hippocampus, Caspase-3, Ultrastructure, Whole body hyperthermia, Propofol

CLC Number: 

  • R456.1
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