JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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P gene of hepatitis B virus in chronic hepatitis B patients who had viral-breakthrough during long-term adefovir dipivoxil monotherapy

LIU Feng, WANG Lei, WANG Li-na, GENG Da-ying   

  1. Jinan Infectious Disease Hospital, School of Medicine, Shandong Universtiy, Jinan 250021, China
  • Received:2007-11-29 Revised:1900-01-01 Online:2008-04-16 Published:2008-04-16
  • Contact: WANG Lei

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Abstract: To investigate the mutations in P gene of hepatitis B virus (HBV) in chronic hepatitis B(CHB) patients who had viral breakthrough during longterm adefovir dipivoxil monotherapy. Methods51 CHB patients who had viral breakthrough during longterm adefovir dipivoxil(ADV) monotherapy(10mg/d, duration >12 months) were enrolled in this study. Sera were collected when viral breakthrough was confirmed, and ALT, HBV DNA(real time quantitative PCR), and sequences of partial HBV P gene were determined. ResultsMutations related to ADV resistance were found in 37 of 51 CHB patients. The frequency of mutation at rt181 was significantly higher than that at rt236 (33 vs 8, P<0.001). Serum HBV DNA load in patients with combination mutation were higher than that with single mutation when the viral breakthrough occurred (6.53±0.45log10 copies/ml vs 5.37±1.08log10 copies/ml, P=0.043). ConclusionMutations in HBV P gene can be developed during ADV monotherapy in CHB patients. The HBV levels may differ in patients with different mutations.

Key words: Hepatitis B, chronic, Hepatitis virus B, Mutation, Adefovir dipivoxil, Drug resistance

CLC Number: 

  • R512.6
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