JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Expression of EMA, EGP-2 and CK19 in peripheral bloods of breast cancer and its clinical significance

SUN Shan-ping, ZANG Yi-xiu, WANG Xiao, CHEN Lian-sheng, TIAN Bin, SUN Tao, JIN Guang-chao   

  1. Department of Breast Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China
  • Received:2007-09-07 Revised:1900-01-01 Online:2008-04-16 Published:2008-04-16
  • Contact: ZANG Yi-xiu

Abstract: To explore the expressions of EMA, EGP-2 and CK19 in peripheral cells of breast cancer and their diagnostic value as micro-metastasis targets for breast cancer. MethodsEMA, EGP-2 and CK19 were determined by flow cytometry in 65 cases of breast cancer and 37 cases of benign breast diseases, also the TNM stages, age, size of tumors, maxillary lymph nodes metastasis and expressions of estrogen receptor and progestin receptor were analyzed. ResultsThe expression rates of EMA, EGP-2 and CK19 in peripheral cells were higher than those in normal controls(P<0.05) and closely related to the TNM stages,size of tumor and maxillary lymph node metastasis(P<0.05). The sensitivity and accuracy of the EMA,EGP-2 and CK19 combination were higher than those of one or two (P<0.05).

Key words: Breast neoplasms, Flow cytometry, CA-15.3 antigen, Genes, Keratin

CLC Number: 

  • R737.9
[1] YU De-Xin, CAEI Ti-Gong, MA Xiang-Xing, ZHANG Xiao-Ming, LI Chuan-Fu. Angiogenesis and maturation of hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 51-54.
[2] DING Tingting, LIU Haochen. Genetic analysis and literature review of a case of non-syndromic tooth agenesis caused by compound heterozygous mutations in WNT10A [J]. Journal of Shandong University (Health Sciences), 2025, 63(3): 92-98.
[3] LIANG Yanchun, YAN Ying, MAI Huaxi, YAO Shuzhong. Therapeutic effect of dienogest in endometriosis-associated pain: from fundamental research to clinical practice [J]. Journal of Shandong University (Health Sciences), 2025, 63(10): 27-33.
[4] LIU Xiangrong, ZHANG Xinsheng, YANG Jinran, YANG Xueyan, LIU Zhao, LIU Yinghua. Association of the ratio of ω-6/ω-3 polyunsaturated fatty acids with various tumor types risk: a systematic review and Meta-analysis [J]. Journal of Shandong University (Health Sciences), 2024, 62(8): 34-48.
[5] WANG Wenqin, GAO Xianlong, GONG Yongfeng, FENG Ke. YBX3 regulates thermogenesis and energy expenditure by regulating UCP1 in brown adipose tissue [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 38-47.
[6] SHI Shuochuan, ZENG Rong, ZHANG Jintao, ZHANG Dong, PAN Yun, LIU Xiaofei, XU Changjuan, WANG Ying, DONG Liang. Bioinformatics-based exploration of potential differential immune genes and immune infiltration signatures in bronchial asthma [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 43-53.
[7] LIANG Zhonghao, ZHUANG Xianghua, HUANG Shan, HAN Xiaolin, HUA Mengyu, JU Liping, CHEN Shihong. Proteomic analysis of brown adipose tissue in diet-induced obese female mice [J]. Journal of Shandong University (Health Sciences), 2024, 62(2): 10-19.
[8] JING Kai, XU Zhiwei, LI Leping. Exploring colorectal cancer related genes and their functions based on GEO [J]. Journal of Shandong University (Health Sciences), 2024, 62(1): 21-30.
[9] QIN Jinjin, CAO Chenyuan, XING Jiejie, AN Yan, HUANG Yuxiang. Predication and bioinformatics analysis of preeclampsia-related Siglec-6 core genes [J]. Journal of Shandong University (Health Sciences), 2024, 62(1): 31-37.
[10] Andong GUO,Sentai DING. Progress in the establishment and application of organoids of bladder cancer [J]. Journal of Shandong University (Health Sciences), 2023, 61(11): 20-26.
[11] SONG Min, CAO Luquan, WU Lilong, WU Shuxia, LIU Jing, ZHANG Juan, LIU Cuiying. Clinical analysis of 9 cases with group A streptococcus infection in obstetrics [J]. Journal of Shandong University (Health Sciences), 2023, 61(11): 89-95.
[12] SONG Yiyun, YU Hui, GAO Zhaoli, LI Xianhua. Protective effects of grape seed proanthocyanidin extract on rats with diabetic kidney disease from the perspective of SIRT1/PGC-1α pathway [J]. Journal of Shandong University (Health Sciences), 2023, 61(1): 1-9.
[13] ZHANG Zhenwei, LI Jia, CHEN Keming. IGF2BP2/m6A/ITGA5 signal axis regulates the proliferation and migration of renal clear cells [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 74-84.
[14] YUAN Mengqi, HUO Fenglei, REN Huiping, GUO Qiushuang, LAN Jing. Effects of Sdccag3 on the osseointegration in hyperlipidemia rats through Wnt pathway [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 66-73.
[15] GUO Sunwei, LIU Xishi. Cracking the enigma of pathogenesis and pathophysiology of adenomyosis [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 6-19.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!