Abstract: To compare the anesthesia effects of nitroglycerin and esmolol in inducing controlled hypotention during spinal surgery. MethodsThirty patients undergoing elective spinal tumor surgery were randomly divided into three groups(n=10）: the control group(A), the nitroglycerin group(B) and the nitroglycerin+esmolol group(C). Group A only received normal saline without controlled hypotention, group B initially received nitroglycerin at 2.5μg/(kg·min) and group C initially received nitroglycerin［2.5μg/(kg·min) ］and esmolol［12.5μg/(kg·min)］. The nitroglycerin dosage was adjusted to maintain the MAP level at 6070 mmHg in groups B and C. Hemodynamic parameters were recorded before controlled hypotention, just at the controlled hypotention, 30?min after controlled hypotention, at the end of controlled hypotention and at the end of the operations. Also the operation time, intraoperative blood loss, blood transfusion amounts and postoperative drainage from the wound were recorded. ResultsThe intraoperative blood loss and blood transfusion cases in groups B and C were much less than those in group A（P＜0.05）. The MAP level of groups B and C significantly decreased during controlled hypotention（P＜0.01）. The HR level of group B significantly increased during controlled hypotention（P＜0.05）and of group C was less than that in group B （P＜0.05）. The duration of the operation was significantly shorter in group C than in group A.

Key words: Nitroglycerin, Esmolol, Hypotention, controlled, Spinal surgery