JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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The relationships between first febrile convulsions and herpesvirus 6 infection

ZHANG Dong-qing, SUN Ruo-peng   

  1. Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2007-09-17 Revised:1900-01-01 Online:2008-02-16 Published:2008-02-16
  • Contact: SUN Ruo-peng

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Abstract: To explore the relationships between the first febrile convulsions and herpesvirus 6 (HHV-6) infection. Methods HHV-6 infection was determined by PCR in 75 children. The clinical characteristics of the first febrile convulsion were compared between those with and without HHV-6 infection. Results HHV-6 infection was found in 26 of 75 patients with the first febrile convulsions. The median age of patients with the first febrile convulsion and HHV-6 infection was significantly lower than those without HHV-6 infection（P＜0.01). The frequency of partial seizures, clustering seizures, long lasting seizures, and postictal paralysis was significantly higher among those with primary HHV-6 infection than that among those without（P＜0.05). The frequency of the first febrile convulsions in infants younger than 1 year and with HHV6 infection was also significantly higher than those without HHV6 infection（P＜0.05). Conclusions HHV-6 infection has a close relationship with febrile convulsions in infants and young children and it often induces more severe convulsions and might be a risk factor for subsequent development of epilepsy.

Key words: Seizure, febrile, Herpesvirus 6, human, Disease attributes

CLC Number: 

  • R742.1
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