JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Changes of expression of mitochondrial cytochrome oxidase subunits Ⅲ and Ⅳ in the rat hippocampus of temporal lobe epilepsy

GAO Jing1，CHEN Wen2，ZHANG Tong-xia3，WANG Xiao-hua1，DAI Ting-jun1，YAO Hong1，ZHAO Xiu-he1，CHI Zhao-fu1，SHAN Pei-yan1   

  1. 1. Department of Neurology, Qilu Hospital of Shandong University；2. Department of Neurology, Jinan Central Hospital；3. School of Medicine, Shandong University
  • Received:2006-11-26 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: CHI Zhao-fu

PDF (PC)

635

Abstract: Objective: To investigate the effect of epilepsy on expressions of cytochrome oxidase(COX) subnuits Ⅲ(COX Ⅲ) and Ⅳ (COX Ⅳ) encoded by mtDNA and nDNA in the rat hippocampus. Methods: Forty male Wistar rats were randomly divided into the saline control group, the acute period group (3h), the silent period group（7d）, the chronic period group(45d) after status epilepticus(SE) and the group which received pilocarpine (PILO) but did not develop SE(n=8 per group). Expressions of COX Ⅲ and COX Ⅳ mRNA and protein in the rat hippocampus were respectively determined by real time quantitative PCR(RQ-PCR) and Western blot. Results: COX Ⅲ mRNA and protein were significantly increased in the group at 3h after SE(P<0.001, P<0.01) compared with the control group. Conclusion: Dysfunction of COX in the hippocampus is related to prolonged seizure during experimental temporal lobe epilepsy and the mitochondria are vulnerable to epilepsy.

Key words: Cytochrome oxidase, Epilepsy, Hippocampus, Mitochondria, Rats, Wistar

CLC Number: 

  • R742.1
[1] ZHU Lin, HU San-Yuan, ZHANG Guang-Yong, DING Xiang-Jiu. Protection of PGE2 against intestinal mucosa injuries in obstructed jaundice rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 12-.
[2] SUN Tao, ZHANG Dao-Lai, XIE Shan-Shan, WANG Yu-Zhuo, FENG Yu-Xin, XIN Hua. Effect of ethanol on expression of connexin 43 in primary culture of neural precursor cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 20-.
[3] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[4] GE Li-Juan, JIN Rui-Feng, WANG Ji-Wen, HU Xin-Sheng, LIKun. Association between the C1236T polymorphism in multi-drug resistance gene 1 and response to antiepileptic drug treatment in epileptic patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 99-102.
[5] WANG Le, LUO Qingxin, WU Sijia, WU Yutong, GE Yilei, YU Yifan, WEI Yun, JI Hanbing, LIU Tiemei, ZHANG Ziyan, XIU Jiawei, XUE Fuzhong, LI Hongkai. Associations between frailty and the risk of epilepsy: a prospective cohort study and Mendelian randomization analysis [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 20-30.
[6] SHEN Yongchun, WEN Fuqiang. Research progress of mitochondrial damage-associated molecular patterns as biomarkers for chronic obstructive pulmonary disease [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 16-20.
[7] ZHAO Zihui, WANG Xuyang, ZHANG Peng, FANG Ningning, SHI Duanbo, YANG Fan, YANG Xiaomei, WU Jianbo. Rapid and accurate assessment of pulmonary hypertension in rats via diaphragmatic puncture method [J]. Journal of Shandong University (Health Sciences), 2024, 62(2): 20-28.
[8] GAO Yujie, LONG Qifu, HU Ying, XU Yuzhen, WANG Ru, YONG Sheng. Bioinformatics identification of the Hub genes and mechanism of hypoxia-induced mitochondrial damage in mouse kidney [J]. Journal of Shandong University (Health Sciences), 2023, 61(9): 57-68.
[9] SONG Yiyun, YU Hui, GAO Zhaoli, LI Xianhua. Protective effects of grape seed proanthocyanidin extract on rats with diabetic kidney disease from the perspective of SIRT1/PGC-1α pathway [J]. Journal of Shandong University (Health Sciences), 2023, 61(1): 1-9.
[10] HU Na, SUN Miao, XING Shasha, XU Danxia, HAI Xiaoming, MA Ling, YANG Li, MIAN Yuchen, HE Rui, CHEN Dongmei, MA Huiming. Evening primrose oil resists oxidative stress in the ovaries of rats with polycystic ovary syndrome [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 22-30.
[11] SHAO Na, YIN Hao, LI Yaran, ZHANG Baokun, HUANG Weiwei, LU Shanshan, TANG Jiyou. Study on the mechanism of Suvorexant treatment ameliorates learning and memory impairment in chronic sleep deprivation mice model [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 17-23.
[12] SONG Luoqing, ZHOU Guoyu, YE Xiang, LU Mei, ZHAO Xinjing. A case report of misdiagnosed cerebral amyloid angiopathy-related inflammation and literature review [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 119-122.
[13] ZHAO Huiwen, XU Lin, SHAN Shan, ZHAO Xiulan. Protective effect of taurine on cognitive deficit induced by 1-bromopropane [J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 14-21.
[14] PAN Pengfei, XU Lisheng, JI Kunqian, WANG Dexiang, LI Yu. Mitochondrial myopathy beginning with respiratory failure: one case and literature review [J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 54-59.
[15] LI Na, GUO Zengli, CHI Lingyi, YANG Lizhuo, MA Zhiyong, FU Zhijie. Mechanism of acute injury of eosinophil EOL-1 induced by formaldehyde [J]. Journal of Shandong University (Health Sciences), 2022, 60(11): 54-62.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd