JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

TAFI level and its mechanism in the process of atherosclerosis in rats

LIU Li-yan, LIU Xiang-qun, CHEN Xiao-an, CHEN Huan-qin   

  1. Department of Geriatrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2006-12-26 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: LIU Xiang-qun

PDF (PC)

962

Abstract: Objective: To investigate the level of TAFI and its mechanism on atherosclerosis. Methods: Forty healthy male Wistar rats were randomly divided into 4 groups (n=10): the control group, the high lipid group, the high lipid + Vitamin D overload group, and the endothelium injury group. Then the content of TC, TG, HDL-C, and LDL-C and the activity of TAFI were determined by a chromogenic assay. Results: Atherosclerosis was successfully established. Hyperlipoidemia stage, fiber hyperplasy arteriosclerosis stage and maturatly plaque stage were also successfully duplicated. TC, TG, LDL-C and the activity of TAFI in the plasma of the three model groups gradually increased compared with the control group （P＜0.01). However, HDL-C in the plasma of the three model groups gradually decreased compared with the control group（P＜0.01 or P＜0.05). The activity of TAFI in the plasma positively related to TG and TC. Conclusion: The activity of TAFI in the plasma is closely correlated with atherosclerosis severity.

Key words: Atherosclerosis, Thrombin activatable fibrinolysis inhibitor, Endothelium, Injuries, Rats, Wistar

CLC Number: 

  • R541.4
[1] ZHU Lin, HU San-Yuan, ZHANG Guang-Yong, DING Xiang-Jiu. Protection of PGE2 against intestinal mucosa injuries in obstructed jaundice rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 12-.
[2] SUN Tao, ZHANG Dao-Lai, XIE Shan-Shan, WANG Yu-Zhuo, FENG Yu-Xin, XIN Hua. Effect of ethanol on expression of connexin 43 in primary culture of neural precursor cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 20-.
[3] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[4] DUAN Yingzhu, DONG Bo, YU Rui. Mendelian randomization study on the association of intrinsic emotions with coronary atherosclerosis risk in patients with rheumatoid arthritis [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 63-71.
[5] LI Xiping, QIU Mei, HUANG Ruifeng, LIN Huihui, LIU Sisi, LUO Hongying, WANG Yuyue, WANG Min, YANG Xiaotong. Research progress on the mechanism of berberines anti-atherosclerosis effects based on the synergistic effect of lipid deposition inhibition and metabolic clearance [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 77-83.
[6] DU Aijia, ZHANG Man, CHEN He, WANG Lixin, SHANG Yingshu. miR-1270-targeted regulation of angiopoietin-like protein 7 inhibits macrophage inflammation and lipid accumulation [J]. Journal of Shandong University (Health Sciences), 2025, 63(2): 1-9.
[7] ZHAO Zihui, WANG Xuyang, ZHANG Peng, FANG Ningning, SHI Duanbo, YANG Fan, YANG Xiaomei, WU Jianbo. Rapid and accurate assessment of pulmonary hypertension in rats via diaphragmatic puncture method [J]. Journal of Shandong University (Health Sciences), 2024, 62(2): 20-28.
[8] XU Tianqi, CHANG Na, ZHANG Shuai, LI Sha, JIAO Bingxuan, YU Xinxin, WANG Ximing. Identification of carotid high-risk plaques by non-alcoholic fatty liver disease based on CTA [J]. Journal of Shandong University (Health Sciences), 2023, 61(12): 36-43.
[9] WU Hong, ZHANG Zhengduo, TANG Yanjin, QI Shaojun, GAO Xibao. Potential intervention effects of 5-methyltetrahydrofolate on atherosclerosis in rats [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 6-13.
[10] HU Na, SUN Miao, XING Shasha, XU Danxia, HAI Xiaoming, MA Ling, YANG Li, MIAN Yuchen, HE Rui, CHEN Dongmei, MA Huiming. Evening primrose oil resists oxidative stress in the ovaries of rats with polycystic ovary syndrome [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 22-30.
[11] ZHAO Huiwen, XU Lin, SHAN Shan, ZHAO Xiulan. Protective effect of taurine on cognitive deficit induced by 1-bromopropane [J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 14-21.
[12] XIE Jiaying, QI Jia, SONG Ming, LI Yulin, WANG Di, JIA Xu, ZHANG Wei, ZHONG Ming, SHANG Yuanyuan. Association between serum β-sheet level and coronary heart disease [J]. Journal of Shandong University (Health Sciences), 2022, 60(1): 21-26.
[13] WANG Haipeng, ZOU Juanjuan, GAO Chunmiao, WANG Xiao, WANG Yan, LI Yanzhong. Construction and significance of a rat model of OSAHS with chronic intermittent hypoxia [J]. Journal of Shandong University (Health Sciences), 2021, 59(2): 7-13.
[14] ZHANG Jijuan, YU Hancheng, WANG Lan, CHEN Nuo, CUI Shumeng, Gao Xibao. Effects of high-fat diet and selenium concentration on antioxidant function in rats [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 95-101.
[15] FU Jieqi, ZHANG Man, ZHANG Xiaolu, LI Hui, CHEN Hong. Molecular mechanism of Toll-like receptor 4 in the aggravation of blood lipid accumulation by inhibiting the peroxisome proliferator-activate receptor γ [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 24-31.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd