Abstract: Objective: To investigate the effect of morphine on renal function. Methods: Fifty Wistar rats were randomly divided into five groups: the control group, the 3d administration group, the 7d administration group, the 3d withdrawal group and the 7d withdrawal group. The concentration of urea nitrogen (BUN), creatinine (CREA) and uric acid in the plasma were determined. Results: Compared with the control group, the plasma BUN concentration was increased in the 7d administration group and the two withdrawal groups, and it was the highest in the the 7d withdrawal group. However, there was no significant difference of the plasma CREA between the two administration groups and the control group. Compared with the control group, the concentration of the plasma uric acid was increased in the two morphine administration groups. Conclusion: Morphine exposure can affect the renal function to some degree, which does not immediately vanish after morphine administration.

Key words: Morphine, Urea nitrogen, Creatinine, Uric acid