JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Correlation between levels of IL-12 and IFN-γ and recurrent spontaneous abortion

WANG Guo-hua, ZUO Chang-ting, WANG Li-jun   

  1. Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong, China
  • Received:2006-11-03 Revised:1900-01-01 Online:2007-07-24 Published:2007-07-24
  • Contact: ZUO Chang-ting

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Abstract: Objective: To explore the correlation between levels of interleukin-12(IL-12) and interferon-γ(IFN-γ) and recurrent spontaneous abortion (RSA). Methods: Thirty patients with RSA( the RSA group), twenty-five normal early pregnant women (the NEP group) and twentyfive normal non-pregnant women( the NNP group) were enrolled in this study. The serum concentrations of IL-12 and IFN-γwere determined by enzyme-linked immunosorbant assay(ELISA). Results: Levels of IL-12 and IFN-γ were significantly higher in the RSA group than in the other groups(P<0.05) and there was a positive correlation between IL-12 and IFN-γ. Levels of IL-12 and IFN-γ were lower in the NEP group than in the NNP group, but there was no statistical difference(P>0.05). Conclusion： IL-12 and IFN-γ may play an important role in the occurrence of RSA.

Key words: Abortion, habitual, Interleukin-12, Interferon type

CLC Number: 

  • R714.21
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