JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Methylcyclopentadienyl manganese tricarbonyl injuries in PC-3M cells

QIN Wen1,WANG Li-xiang2,ZENG Ji-ping3,CHEN Wei-wen3,ZHANG Ya-lun3   

  1. 1. School of Public Health; 2. Institute of Phamocology, School of Medicine; 3. Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University
  • Received:2006-12-13 Revised:1900-01-01 Online:2007-07-24 Published:2007-07-24
  • Contact: ZENG Ji-ping

Abstract: Objective: To explore the effect of methylcyclopentadienyl manganese tricarbonyl (MMT) on PC-3M cells. Methods: The MTS method was used to determine the time and concentration curves induced by MMT on PC-3M cells. Spectrophotometry was used to determine the changes of ROS, LDH and MDA and the activity of SOD. Results: The survival viability of cells decreased with MMT in a dose-and concentration-dependent manner. After induction by 2mmol/L MMT for 24h, the survival rate of PC-3M cells was 48.55%(P<0.01). In this process, the ROS, LDH and MDA obviously increased(P<0.01), and the activity of SOD significantly decreased(P<0.01). Conclusion: MMT injures PC-3M cells.

Key words: MMT, Prostate, Injury

CLC Number: 

  • R994.6
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