JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Preparation and quality control of penciclovir liposome

SONG Li-jie, WANG Wei-hong, LU Jin-ling   

  1. Institute of Pharmaceutical Analysis, School of Pharmacy, Shandong University, Jinan 250012, Shandong, China
  • Received:2006-05-16 Revised:1900-01-01 Online:2007-06-24 Published:2007-06-24
  • Contact: WANG Wei-hong

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Abstract: Objective： To study the preparation of penciclovir liposomes and its quality control. Methods： The optimum preparation technology was established by a uniform design. Negative staining and the laser scattering particle size distribution analyzer were used to study the structure and size of liposomes. A gel column and Kratio spectrophotometry were developed to determine the entrapment efficiency. Results： The average size of liposomes was 426.8nm. The entrapment efficiency was 60.76%. Conclusion： The preparation of penciclovir liposome is practicable and should be investigated further.

Key words: Penciclovir, Lliposome, Quality control

CLC Number: 

  • R944
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