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Association of IL-1 receptor antagonist gene 2/2 genotype with increased susceptibility for Behcet′s disease with uveitis

LIU Xiang-dong1，SUN Shan-hui2，XIANG Dong-jie2，MU Guo-ying3，WANG Yun-shan2   

  1. 1. Department of Clinical Laboratory, Shandong Provincial Hospital；2. Medical Research and Diagnostic Center, Jinan Central Hospital；3. Department of Ophthalmology, Jinan Central Hospital
  • Received:2007-01-22 Revised:1900-01-01 Online:2007-05-24 Published:2007-05-24
  • Contact: WANG Yun-shan

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Abstract: Objective: To investigate a possible association of specific polymorphisms of interleukin 1(IL-1) receptor antagonist (IL-1ra) genes with susceptibility for Behcet′s disease (BD) with uveitis. Methods: The genotypes of a total of 27 BD patients and 71 controls were determined for IL-1ra variable number of tandem repeat polymorphisms (for five different alleles) by PCR. χ2-analysis was used to compare the allele and genotype frequencies of patients and controls. Results: There was no difference in the allele or genotype frequencies of IL-1ra between patients with BD and the controls (P＞0.05). The 2/2 genotype of IL-1ra polymorphisms was identified as an increased risk of BD with uveitis(OR=3.3).No association was produced for other investigated polymorphisms in the genotype or allele frequencies of IL-1ra between the BD patients or BD patients with uveitis and the control. Conclusion： Susceptibility to BD with uveitis is enhanced in individuals carrying the 2/2 genotype of IL-1ra polymorphisms.

Key words: Behcet′s syndrome, Uveitis, Interleukin-1, Genotype

CLC Number: 

  • R773
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