Abstract: Objective： To explore the therapeutic effect of the Yishenhuoxue capsule on basic fibroblast growth factor (bFGF) and transformation growth factorβ1 (TGF-β1) of hyperhomocysteinemia rats. Methods: Using randomized single blind method, 80 Wistar rats were divided into 8 groups: the model group, the normal group, the large dose of the Yishenhuoxue capsule group, the little dose of the Yishenhuoxue capsule group, the Western Medicine group (folic acid, VitB12, and VitB6), the Dahuangzhechong pill group, the preventive group and the blank group. The rats were induced hyperhomocysteinemia except for those in the normal group. The basic fibroblast growth factor(bFGF), transformation growth factorβ1 (TGF-β1) mRNA in aorta vessel were determined by the in situ hybridization. Result:Yishenhuoxue capsule could decrease the expression of bFGFmRNA(P=0.000), TGF-β1 mRNA(P=0.032) in hyperhomocysteinemia rats better than other medicines. Conclusion: Yishenhuoxue capsule could improve the endothelial cell function, reduce the part inflammation reaction of the part vessel, restrain the proliferation of vessel smooth muscle cells and endothelial cells, prevent the development of atherosclerosis.

Key words: Yishenhuoxue capsule, Hyperhomocysteinemia, Wistar rats, In situ hybridization, basic fibroblast growth factor(bFGF), Transformation growth factorβ1 (TGFβ1)