Abstract: Objective： To observe the effect of grape seed proanthocyanidin extracts （GSPE）on plasma advanced glycation end products (AGEs) and myocardial ultrastructures of streptozotocin（STZ） induced diabetic rats． Methods： Male Wistar rats were subjected to 0.1% STZ through the tail vein to induce diabetics．Then, they were randomly divided into two groups: diabetic model (DM) group （DM1,n=8）and GSPEtreatment diabetic group (DM2,n=12, 250?mg·kg-1·d-1)． Nondiabetic Wistar rats were enrolled in other two groups: the control group（C1, n=10） and the GSPE treatment group（C2 group, n=10, 250?mg·kg-1·d-1）． After 24 weeks， all rats were killed, and the fasting plasma glucose， glycosylated hemoglobin and AGEs were determined． Changes of myocardial ultrastructure were produced by an electronic microscope． Result： Plasma AGEs of DM2 group was lower than that of DM1 group (t=2.792，P=0.02)． The myofibrillaes and the chondriosomees disordered in DM1 group， but changed after the GSPE treatment． Conclusions： GSPE can inhibit nonenzymatic reactions of glycosylation in STZ-induced diabetic rats and protect the myocardial ultrastructure．

Key words: Grape seed proanthocyanidin extracts, Diabetic cardiomyopathy, Glycosylation end products, advanced, Myocardial ultrastructure, Rats, Wistar