JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effects of anti-epileptic drugs on the blood levels of homocysteine, folate and vitaminB12

WANG Xiao-hua1, ZAHNG Tong-xia2, ZHAO Xiu-he1, Gao Jing1, LIU Xue-wu1, CHI Zhao-fu1   

  1. 1.　Department of Neurology, Qilu Hospital of Shandong University；2. School of Medicine, Jinan 250012, Shandong, China
  • Received:2006-11-10 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: CHI Zhao-fu

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Abstract: Objective: To investigate the effect of antiepileptic drugs(AEDs) on the blood levels of homocysteine, folate and vitaminB12. Methods: There were 3 groups tested: ①88 epipleptic patients, taking a single AEDs; ②epileptic control group, 30 epileptic patients not taking AEDs; ③normal control group, 40 healthy controls. The levels of homocysteine, folate and vitaminB12 were determined by a fluorescence quantity method and an electrochemistry radiation immunity. Results： In epileptic patients taking a single carbamazepine (CBZ) and phenytoin(PHT), the levels of homocysteine were significantly higher and the levels of folate were significantly lower than those of the control group(P＜0.001). The levels of homocysteine, folate and vitaminB12 were not significantly changed in patients taking valproic acid(VPA)(P＞0.05). Conclusions： Homocysteine levels of epileptic patients taking CBZ and PHT were significantly increased whereas the folate levels of epileptic patients taking CBZ and PHT were signifacantly decreased. An adequate dosage of folate and vitaminB12 for epileptic patients is helpful in preventing angiocardiopathy and cerebrovascular diseases.

Key words: Epilepsy, Anticonvulsants, Homocysteine, Folic acid, VitaminB12

CLC Number: 

  • R742.1
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