JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Structural changes of myocardium sleeves in canine pulmonary veins due to sustained atrial fibrillation

MA Xiao, ZHANG Wei, YANG Guirong, ZHONG Ming, LI Li, ZHANG Yun   

  1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education　and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of　Shandong University, Jinan 250012, Shandong, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: ZHANG Wei

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Abstract: Objective: To study structure changes of myocardium sleeves in canine pulmonary veins(PVs) due to sustained atrial fibrillation(AF). Methods: The tissue and cell structure in individual veins was assessed by lightmicroscopy using HE and Masson′s Trichrome staining. Results: Compared with control dogs, sections from AF dogs showed cellular hypertrophy, disarranged cell bundles and increasing connective tissue. Some myocytes were surrounded by collagen tissue and myofilament was disrupted. Masson′s Trichrome stain showed that from the left atrium towards the vein, and the myocardial sleeves were gradually attenuated and ended in a rounded tip surrounded by fibrous tissue. Within myocardial sleeves, sharp transitions in fiber orientation were sometimes observed. It was apparent that myocytes on the endocardial side of myocardial sleeves were cut transversely in longitudinal sections. Samples from AF dogs showed, however, collagen tissue increased markedly and disrupted some areas. Conclusion: The special structure of the myocardial sleeve in PVs and its structural remodeling due to sustained AF may provide a substrate for forming micro reentry, which is an important mechanism for the occurrence and maintenance of AF.

Key words: Atrial fibrillation, Pulmonary vein, Myocardium sleeve, Canine

CLC Number: 

  • R541.75
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