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Primary study on the expression of bFGF and TGF-β in the posterior sclera of human fetuses with family-based myopia

XIAO Ying1，LI Jing-hai2，ZHOU Ya-bin3，GAO Zhi-juan1，TANG Wei3   

  1. 1. Department of Ophthalmology， Second Hospital of Shandong University；2. Department of Ophthalmology， Qilu Hospital of Shandong University；3. Institute of Pathogenic Biology
  • Received:2006-12-30 Revised:1900-01-01 Online:2007-03-24 Published:2007-03-24
  • Contact: XIAO Ying

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Abstract: Objective: To evaluate the expression of basic fibroblast growth factor(bFGF) and transforming growth factor-beta(TGF-β) of the posterior sclera in human fetuses of the same month. Methods: Sixteen eyes of human 14-week fetus were divided into two groups: the experimental group whose parents were myopia with a refraction over -4.00D and the control group whose parents were without myopia. The expressions of bFGF and TGF-β in the posterior sclera were determined and quantitatively analyzed by immunohistochemistry and RT-PCR. Results: The expression of bFGF in the experimental group was significantly higher than that in the control group (P＜0.05), while on the contrary, the expression of TGFβin the experimental group was significantly lower than that in the control group (P＜0.05). Conclusion： The expressions of bFGF　and TGF-β in the posterior sclera of the fetal eyes of the same fetal month are significantly different between myopia families and non-myopia families.

Key words: Human fetus, Sclera, Myopia, bFGF, TGF-β

CLC Number: 

  • R778.1
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