Abstract: Objective: To investigate the correlation of polymorphisms of 1166 A/C of Angiotensin Ⅱ type Ⅰ receptor gene ( AT1R 1166A/C) and angiotensin Ⅱ with hereditary susceptibility and clinical phenotype of HBV-induced liver cirrhosis. Methods: Peripheral blood samples were collected from 102 patients with HBV-induced liver cirrhosis and 106 healthy donors. Polymorphisms of the 1166A/C of AT1R gene were determined by PCR-RFLP, and plasma concentrations of Angiotensin Ⅱ were measured by RIA. Results: Plasma concentrations of angiotensin Ⅱ of the liver cirrhosis group were significantly higher than those of the control group (P＜0.05). Plasma concentrations of angiotensin Ⅱ were also significantly higher in patients with the Child-Pugh C and B grades than those in patients with the Child-Pugh A grade (P＜0.01 and P＜0.05, respectively). They were also higher in patients with severe esophageal varices and an ascites than those with light esophageal varices and without ascites (P＜0.05). There was not a significant difference in genotype and allele frequency of AT1R 1166A/C between the liver cirrhosisgroup and the control group (P＞0.05). Conclusion: Plasma concentration of angiotensin Ⅱ is related to the progression of liver cirrhosis and the 1166A/C polymorphism of the AT1R gene is not related to hereditary susceptibility or progression of liver cirrhosis.

Key words: epatitis B, Liver cirrhosis, Angiotensin Ⅱ, Receptors, angiotensin