JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression and significance of c-kit in conventional osteosarcoma

WEI Hong， LI Jin-song， LIU Wen-jun   

  1. Department of Pathology，School of Medicine, Shandong Univercity， Jinan 250012， Shandong, China
  • Received:2006-12-24 Revised:1900-01-01 Online:2007-03-24 Published:2007-03-24
  • Contact: LI Jin-song

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Abstract: Objective: To investigate the expression of c-kit in conventional osteosarcoma and their relationships with clinicopathological parameters and prognostic value. Methods: The expression of c-kit was determined in 40 patients with conventional osteosarcoma by immunohistochemistry. Their relationship with prognosis was statistically analyzed. Results: (1)The expression rate of c-kit in conventional osteosarcoma was 62.5%．（2）The conventional osteosarcoma with a high expression of c-kit was prone to recur locally. (3)The post-operative survival of patients with highly expressed c-kit was significantly lower than that of patients with lowly expressed c-kit．Conclusion： The expression of c-kit is related to the biological behavior of osteosarcoma in conventional osteosarcoma, and it is valuable in judging the prognosis and therapy for osteosarcoma．

Key words: Osteosarcoma, Prognosis, C-kit, Drug therapy

CLC Number: 

  • R738.1
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