JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Expression of PDGF and its receptor on pancreas fibrosis in rats

WANG Dongsheng1, LIU Qian2, KOU Yan3   

  1. 1. School of Medicine, Shandong University, Jinan 250012; 2.Department of Digestion,Shandong Provincial Qianfoshan Hospital, Jinan 250014; 3. Department of Burn, Jinan Fourth People′s Hospital, Jinan 250031
  • Received:2005-08-12 Revised:1900-01-01 Online:2006-04-24 Published:2006-04-24

Abstract: Objective: To study the expression and significance of PDGF and its receptor in the process of pancreas fibrosis. Methods: The animal model of chronic pancreatitis was established by injection of 2% TNBS to rat′s pancreatic duct. Expressions of PDGF, PDGFR and αSMA were determined in pancreas tissues in different stages by using immnnohistochemistry technique. Results: Expressions of PDGFB, PDGFRβ and αSMA were stronger in model than in control group on the fourth week. There was a positive correlation between αSMA and PDGFB and PDGFRβ, and no correlation between αSMA and PDGFA and PDGFRα. The expressions of PDGFB and PDGFRβ were stronger than those of PDGFA and PDGFRα with a significant difference in model group. Conclusion: PDGFB and PDGFRβ are mainly to act play a key role in pancreas fibrosis and development.

Key words: Receptors, plateletderived growth factor, Pancreatitis, Rat, Wistar

CLC Number: 

  • R576
[1] WUYi-Na, GE Zhi-Ming, LI Fang, HE Hong, JIANG Hong, ZHANG Yun. Expressions of angiotensin converting enzyme 2 mRNA and protein in the kidneys in spontaneously hypertensive rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 5-.
[2] ZHU Lin, HU San-Yuan, ZHANG Guang-Yong, DING Xiang-Jiu. Protection of PGE2 against intestinal mucosa injuries in obstructed jaundice rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 12-.
[3] SUN Tao, ZHANG Dao-Lai, XIE Shan-Shan, WANG Yu-Zhuo, FENG Yu-Xin, XIN Hua. Effect of ethanol on expression of connexin 43 in primary culture of neural precursor cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 20-.
[4] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[5] WANG Xiao-Lei, ZHANG Hai-Thao, ZHANG Hui, GUO Cheng-Hao. Protective effects of shuxuening injecta on vascular  endothelial  cell injury in vitro due to iodine excesses [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 38-.
[6] LU Xiang-Dong, YANG Wei, XU Guang-Meng, QU Yuan-Ming. Expression and role of PPAR-γin meningiomas and troglitazone induced meningiomas cell apoptosis in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 65-.
[7] ZHANG Xiao-Yan, LI Gang, WANG Ling-Beng. Effects of different dosages of Sufentanil in induced general anesthesia  period on blood rheology cortisol in spinal operations [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 76-79.
[8] WANG Xin, XING Chun-Yan, YANG Yan-Ping. Serum phosphopyruvate hydratase in diagnosis of invasive Candida albicans infection [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 92-94.
[9] YU De-Xin, CAEI Ti-Gong, MA Xiang-Xing, ZHANG Xiao-Ming, LI Chuan-Fu. Angiogenesis and maturation of hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 51-54.
[10] DONG Ping, SHEN Haitao, QIAO Yaqin, LU Yan. Role of autophagy in the regulation of APAP liver injury and liver regeneration process [J]. Journal of Shandong University (Health Sciences), 2026, 64(5): 42-49.
[11] DONG Zihao, LIU Zhe, WANG Hao, YU Chenxi, YANG Guang, FENG Haotian. Incidence of early postoperative complications following different capsulotomy methods in hip arthroscopy [J]. Journal of Shandong University (Health Sciences), 2026, 64(5): 83-87.
[12] CHEN Yumeng, ZHANG Yue, ZHANG Wulin, YANG Guoxing, XU Yanhui, HAN Aijun, LIU Caijuan, GUO Yuyu, CHEN Zhimin. Evaluating the efficacy of large language models in answering questions from parents of children with congenital lens dislocation [J]. Journal of Shandong University (Health Sciences), 2026, 64(5): 88-95.
[13] MA Yihan, YUAN Xinyun, LI Jiani, HAN Xu, DIAO Qidi, WANG Yan, CHU Xu, ZHANG Kun, HU Lei. Relationship between childhood abuse and frequent nightmares in adults with depressive disorders: mediating effect of somatic symptoms and moderating role of social support [J]. Journal of Shandong University (Health Sciences), 2026, 64(5): 96-105.
[14] WANG Ye, WANG Gang, NAN Haiou, CAI Yuling, LI Jiayu, WANG Haifeng, YAN Yingjie, JIANG Zhiwei. Correlation between perioperative heart rate variability and inflammatory indicators in gastric cancer patients [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 23-30.
[15] LI Jingxiu, LI Zhonghui, LI Wentian, WANG Yunan, SONG Zehui, ZHUANG Dayong, HE Qingqing, ZHOU Peng. Preliminary application of photoelectric detection devices in thyroid cancer surgery [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 31-37.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd