Abstract: Objective: To estimate the seroprevalence of HHV8 infection and its correlation with hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis infection among blood donors in Shandong region. Method: Five hundred and twenty serum were tested for HHV8 IgG antibody with ELISA by using HHV8 ORF K8.1 peptides as antigen. Results: The mortality of positive HHV8 IgG antibody in blood donors from Jinan region was 5.962%（31/520）, and had a trend of increase with the blood donors′ increasing age, but it was not associated with exposure to HBV, HCV or syphilis. Conclusion: There is a certain rate of HHV8 infection in blood donors of Shandong. It is necessary to screen blood donors for HHV8.

Key words: Blood donors, Human herpesvirus 8, Immunoglobulin G