JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Experimental study of Metoprolol on cardiac fibrosis in rabbits with acute myocardial infarction

WANG Qing, SUN Xue-lin, XING Qi-chong, YAN Su-hua, HU He-sheng   

  1. Department of Cardiology, Qianfo Mountains Hospital, School of Clinical Medicine, Shandong University, Jinan250014,Shandong, China
  • Received:2005-09-01 Revised:1900-01-01 Online:2006-12-24 Published:2006-12-24
  • Contact: WANG Qing

Abstract: To investigate the precautionary and therapeutic action of Metoprolol on collagen remodeling after acute myocardial infarction(AMI) in New Zealand rabbits. Methods： MI was established by ligating the left ventricular branch of coronary artery in 24 New Zealand rabbits who were randomly divided into 2 groups, Metoprolol group and AMI group. And the other 8 rabbits were enrolled into sham operation group. After test, 8 rabbits survived in Metoprolol group, 10 in AMI group, and 7 in sham operation group. The serum level of IL6 was measured before operation, 1 day and 4 days after operation, and the level of hsCRP before operation, 1 day and 7 days after operation. The serum levels of PⅠCP and PⅢNP were measured before operation and at 1, 4，7, 14, 28, 56 days after operation in all New Zealand rabbits. All indexes were measured by ELISA. After the experimental animals were executed at 56 days, pieces of myocardium in farction zone and in uninfarction zone were excised, and the deposition content of collagen I and Ⅲ were measured by

Key words: Rabbit, Creactive protein, Acute myocardial infarction, Inflammation, Metoprolol, Myocardial infarction, Collagen remodeling , Mural thrombos

[1] XU Ning-Yu, WANG Lei, HAO En-Kui, SU Guo-Hai. Effects of atorvastatin given before acute PCI on inflammatory mediators and left ventricular function in STEMI [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 69-72.
[2] HAO Yue-Wei, LIU Xue-Ping, ZHAO Ting-Ting, ZHENG Min, WANG Yi-Bing. Relationship between the COX-2 gene polymorphisms and atherothrombotic ischemic stroke [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 95-98.
[3] LYU Mingyue, SUN Hanchen, LUO Qingxin, XU Zhaoke, XU Ruize, ZHANG Shuo, YAN Luning, HU Xifeng, ZHAO Qingbo, ZHU Gaopei, XUE Fuzhong. Therapeutic effect of nifedipine and metoprolol on heart disease [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 1-10.
[4] SHEN Lujia, LU Tianwei, GONG Weiming, ZHAO Yansong, WANG Shukang, YUAN Zhongshang. Application of metabolomic risk score in predicting cardiovascular outcomes in patients with type 2 diabetes mellitus [J]. Journal of Shandong University (Health Sciences), 2025, 63(8): 69-78.
[5] Stereoscopic Electrocardiogram Professional Committee of Henan Biomedical Engineering Society, Electrocardiogram Professional Committee of China Medical Education Association, Electrocardiogram Professional Committee of Shandong Association of Traditional Chinese Medicine, Electrocardiogram Physiology and Pacing Specialized Branch of Qingdao Medical Association, Remote Cardiac Professional Committee of National Medical Technology Market Association. Expert consensus on standardization of diagnostic criteria of vectorcardiogram(2025) [J]. Journal of Shandong University (Health Sciences), 2025, 63(7): 1-10.
[6] WEN Xuelong, LIU Anhui, CHEN Jingwei, WU Mengting, YANG Min. A Meta-analysis of the timing of coronary artery bypass grafting surgery for acute non-ST myocardial infarction [J]. Journal of Shandong University (Health Sciences), 2025, 63(5): 60-70.
[7] LIU Shaoting, ZHANG Weiwei, RAN Qian, WANG Jian. Dietary emulsifiers and intestinal health [J]. Journal of Shandong University (Health Sciences), 2024, 62(8): 18-26.
[8] SUN Lina, BAI Hongyan, NIU Zongge, ZHANG Fushuai, QU Yiqing. Construction and evaluation of an online clinical risk model for predicting in-hospital mortality in patients with ARDS based on SII [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 10-20.
[9] TIAN Lijun, SANG Yujie, SUN Yujing, HAN Bing, QIN Chengyong, QI Jianni. The predictive value of systemic immune-inflammation index for immune checkpoint inhibitor treatment-related adverse reactions in patients with primary liver cancer [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 48-53.
[10] SHEN Haitao, QIAO Yaqin, DONG Ping, LU Yan. Effects of programmed necrosis and ferroptosis regulated by toll-like receptor 4 on acetaminophen-induced liver injury [J]. Journal of Shandong University (Health Sciences), 2024, 62(4): 1-8.
[11] XU Xinjun, SHAO Liting, CHEN Ying, LIU Huifang, YANG Yujuan, ZHANG Yu, WANG Hanrui, SONG Xicheng. Comparison of the therapeutic effect of SYN008 with Xolair® in allergic asthma mice: inflammation and remodeling [J]. Journal of Shandong University (Health Sciences), 2024, 62(12): 1-10.
[12] YANG Xiaozhe, ZHAO Yan, QING Hui, WANG Xiangdong, ZHANG Luo. PM2.5 induces inflammatory response in nasal epithelial cells through TLR4/NF-κB pathway [J]. Journal of Shandong University (Health Sciences), 2023, 61(9): 47-55.
[13] LIU Jinbo, LIU Kaiwen, XIANG Chongxin, CHENG Lei. Protective effects of crocin on intervertebral disc degeneration [J]. Journal of Shandong University (Health Sciences), 2023, 61(9): 84-93.
[14] BU Meiling, WANG Jinrong, FENG Mei, SUN Lifeng. Mechanism of FOXM1 in acute exacerbation of asthma induced by respiratory virus infection in mice [J]. Journal of Shandong University (Health Sciences), 2023, 61(6): 1-9.
[15] ZHAO Yuanyuan, LU Juntao, WU Xiaohua. Effects of human umbilical cord mesenchymal stem cell-derived exosomal miR-100 on inflammation of ovarian granulosa cells in polycystic ovary syndrome [J]. Journal of Shandong University (Health Sciences), 2023, 61(5): 51-58.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd