侧脑室注射内吗啡肽-1降低神经病理性疼痛大鼠海马和PAG IL-6mRNA的表达

Abstract

Abstract: To investigate the effect of intracerebroventricular (i.c.v.) injection of endomorphin1 (EM1) on IL6 mRNA expression level in hippocampus and on PAG in chronic constriction injury (CCI) model of rats. Methods： The CCI model was established and given endomorphin1 (20 μg/20 μl, i.c.v) once daily for 3 consecutive days. The control rats were operated on and injected NS. The mechanical and the thermal pain threshold were measured 1 day before operation and 7 days after operation. The expression level of IL6 mRNA was measured by in situ hybridization. Results： Mechanical allodynia and thermal hyperalgesia were induced in CCI rats. In addition, the expression level of IL6 mRNA in hippocampus and PAG markedly increased. Intracerebroventricular injection of EM1 increased the basic pain threshold of the rats, reversed the CCIinduced existing neuropathic pain state and significantly suppressed the increased expression level of IL6 mRNA induced by CCI. Conclusion： EM1 may be involved in the modulation of neuropathic pain mediated by IL6 in hippocampus and PAG

Key words: Chronic constriction injury, Endormorphin1, Interleukin

SUN Tao,SONG Wen-ge,YAO Shang-long,FU Zhi-jian. [J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(10): 1028-1031.

References

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