JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Differentiation of cardiomyocytes from bone marrow mesenchymal

SONG Zhao-feng,JI Xiao-ping,WANG Xiao-rong, JIANG Shi-liang,ZHANG Xiao-fang, WAGN Rong, ZHANG Yun   

  1. Department of Cardiology, Qilu Hospital of Shandong University, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China
  • Received:2006-02-10 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: SONG Zhao-feng

Abstract: To investigate the factors of differentiation of cardiomyocytes from rat mesenchymal stem cells in vitro． Methods: Mesenchymal stem cells(MSCs) were isolated from cannon born and thighbone of the rats, and were induced by 5azacytidine after culture and expansion. The proliferation and the differentiation were observed. The αactin and the cTnI were detected. Results: αactin and cTnI were found after induced by 5azacytidine. MSCs was similar to cardiomyocytes in physiology. Conclusion: MSCs can be translated to cardiaclike muscle cells after induced by 5azacytidine in vitro.

Key words: Stem cells, Cell culture, Differentiation, Rats, Wistar

[1] WANG Wei, WANG Yi-Feng, ZHANG Ling-Mei, LIN Qiong-Yan, HUANG Ju. umorigenicity and invasion of side population in human ovarian epithelial cancer OVCAR3 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 8-11.
[2] ZHU Lin, HU San-Yuan, ZHANG Guang-Yong, DING Xiang-Jiu. Protection of PGE2 against intestinal mucosa injuries in obstructed jaundice rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 12-.
[3] SUN Tao, ZHANG Dao-Lai, XIE Shan-Shan, WANG Yu-Zhuo, FENG Yu-Xin, XIN Hua. Effect of ethanol on expression of connexin 43 in primary culture of neural precursor cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 20-.
[4] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[5] ZHANG Hui, SHI Qing, HOU Huai-Shui, LI Dong. Culture of human cord mesenchymal stem cells using animal serum-free medium and hepatogenic differentiation [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 88-.
[6] ZHAO Canbin, SHAO Jiang, GUAN Donghui, QIN Ying, DING Qiang, GUO Liang, WANG Weiwei, CHEN Wei, YAN Xiaolong, ZENG Ping. Mechanism of luteolin regulating Wnt/β-catenin signal pathway in inflammatory microenvironment to promote chondrogenic differentiation of bone marrow mesenchymal stem cells [J]. Journal of Shandong University (Health Sciences), 2025, 63(7): 11-22.
[7] XING Kai, ZHENG Qiang, SUN Jinshu, LIU Xiaolin, WANG Zhengjun. Comparison of osteogenic induction methods for human valve interstitial cells in vitro [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 11-18.
[8] LIU Haixia, HUANGFU Shasha, SANG Xiaoyu, CUI Dongqing, BI Jianzhong, WANG Ping. Effects of mesenchymal stem cells on ferroptosis in experimental autoimmune encephalomyelitis mice [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 1-8.
[9] GUO Shuhua, FAN Yang, TIAN Feng, WANG Chuanxin, DU Lutao, LI Peilong, GUO Xing, XU Shuo. Role of microfibril-associated protein 3 in regulating mesenchymal transition of glioma stem cells [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 9-16.
[10] SHEN Feifei, LI Dong, LIU Linghong, JU Xiuli. Umbilical cord mesenchymal stem cells sheets treated by small intestinal submucosa promote wound healing [J]. Journal of Shandong University (Health Sciences), 2024, 62(4): 68-77.
[11] LIU Wenzhu, LIU Fuchen. Differentiation and molecular pathological analysis of motor neurons in a case of spinal muscular atrophy [J]. Journal of Shandong University (Health Sciences), 2024, 62(4): 92-100.
[12] WANG Tengwei, LIN Hui, ZHANG Mingxiang, SUN Jinpeng, ZHANG Daolai. P19 activates the Gq pathway of GPR56 to promote browning of beige adipose [J]. Journal of Shandong University (Health Sciences), 2024, 62(3): 20-27.
[13] ZHAO Zihui, WANG Xuyang, ZHANG Peng, FANG Ningning, SHI Duanbo, YANG Fan, YANG Xiaomei, WU Jianbo. Rapid and accurate assessment of pulmonary hypertension in rats via diaphragmatic puncture method [J]. Journal of Shandong University (Health Sciences), 2024, 62(2): 20-28.
[14] YAN Xiaolong, QIN Ying, SHAO Jiang, CHEN Dongfeng, GUAN Donghui, ZHAO Canbin. Mechanism of curcumin regulating bone formation via the Wnt/β-catenin signaling pathway [J]. Journal of Shandong University (Health Sciences), 2024, 62(10): 76-86.
[15] LI Zhe, ZHANG Zhenkun, ZHANG Shukun. SMARCA2-deficient undifferentiated bowel cancer: a report of 4 cases and literature review [J]. Journal of Shandong University (Health Sciences), 2023, 61(11): 82-88.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd